Protein Alignment toy and ALX1

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_008913.2
• Gene: ALX1 / 8092
• HGNCID: 1494
• Length: 326
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 82/278 - (29%)
• Similarity: 118/278 - (42%)
• Gaps: 51/278 - (18%)

  Fly   167 NESVYEKLRMFNGQTGG---WAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFS 228
            |||.|.|      .:.|   .|:.|......|:.|...:....|..|..       :.|.|.|
Human    37 NESFYSK------ASAGKCVQAFGPLPRAEHHVRLERTSPCQDSSVNYG-------ITKVEGQ-- 86

  Fly   229 VEVSHTNSHDSTSDGNS-------------EHNSSGDE-DSQMRLRLKRKLQRNRTSFSNEQIDS 279
              ..||..:.:..:.||             |.:..||: ||.:....||   |:||:|::.|::.
Human    87 --PLHTELNRAMDNCNSLRMSPVKGMQEKGELDELGDKCDSNVSSSKKR---RHRTTFTSLQLEE 146

  Fly   280 LEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTST 344
            |||.|::||||||:.||:||.:..|.|||:||||.|||||||:.|:.             |:...
Human   147 LEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERY-------------GQIQQ 198

  Fly   345 ANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLP-EASNGPTVLGGEANTTHTSS 408
            |.:....|...||....:|.|.|.|:.........|.:.|..|| :.|:..|.......|..:.:
Human   199 AKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDTSSCMTPYSHSPRTDSSYT 263

  Fly   409 ESPPLQPAAPRLPLNSGF 426
            .....|.....:|||:.|
Human   264 GFSNHQNQFSHVPLNNFF 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	46/115 (40%)
		Homeodomain	267..322	CDD:459649	33/54 (61%)
ALX1	NP_008913.2	Homeodomain	133..189	CDD:459649	34/58 (59%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		21/103 (20%)
		OAR	302..320	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319