Protein Alignment toy and PAX8

DIOPT Version :9

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_003457.1
• Gene: PAX8 / 7849
• HGNCID: 8622
• Length: 450
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 177/529 - (33%)
• Similarity: 245/529 - (46%)
• Gaps: 134/529 - (25%)

  Fly    13 PHSSVGQSTLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGC 77
            ||:|:         .:||.|:|||||.:|||||||:..||:||:|||.|.|||||||.|:||:||
Human     2 PHNSI---------RSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGC 57

  Fly    78 VSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNI 142
            ||||||||||||||:|..||||||:|||..||:||.||||:.|::||||||||||:|.||::|.:
Human    58 VSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTV 122

  Fly   143 PSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPA-----A 202
            ||||||||::|.    |.||.             ||        .|.::..|..:|.|.     :
Human   123 PSVSSINRIIRT----KVQQP-------------FN--------LPMDSCVATKSLSPGHTLIPS 162

  Fly   203 SVVTSPANLSGQAD---------------RDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGD 252
            |.||.|.  |.|:|               :....||::..|.:.|...|.||.|      :|||
Human   163 SAVTPPE--SPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQS------SSSG- 218

  Fly   253 EDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRR 317
                     .||..|. .:||...::.||..|||.|||:.:|..
Human   219 ---------PRKHLRT-DAFSQHHLEPLECPFERQHYPEAYASP--------------------- 252

  Fly   318 AKWRREEKMRTQRRSADTV-DGSGRTSTANNPSGTTASS-----------SVATSNNSTPGIVNS 370
            :..:.|:.:........|: ||....:.:|.|.|...|:           |.......||.:.:|
Human   253 SHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSS 317

  Fly   371 AINVAERTSSALVS-----------NSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNS 424
            :...:..:|||.:.           |:.|.|::......|:|..:......|.|....|.:|.:.
Human   318 SSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSG 382

  Fly   425 GFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLS--LGSPYVSAHHRNTACN 487
            ..:...|:|...:|  ...|:.:....||     ..:|...:..|.|  |.|||    :.::...
Human   383 QGSYASSAIAGMVA--GSEYSGNAYGHTP-----YSSYSEAWRFPNSSLLSSPY----YYSSTSR 436

  Fly   488 PSAAHQQPP 496
            |||    ||
Human   437 PSA----PP 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	90/123 (73%)
		COG5576	<253..368	CDD:227863	25/126 (20%)
		Homeobox	269..322	CDD:395001	11/52 (21%)
PAX8	NP_003457.1	PAX	9..133	CDD:128645	90/123 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..222		19/80 (24%)
		Pax2_C	337..448	CDD:315141	27/120 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010