DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and pitx1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001035436.3	Gene:	pitx1 / 678598	ZFINID:	ZDB-GENE-060421-3623	Length:	285	Species:	Danio rerio

Alignment Length:	333	Identity:	90/333 - (27%)
Similarity:	132/333 - (39%)	Gaps:	83/333 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 LPPAASVVTSP-ANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRL 261
            ||.:||..... .|.|.::  .|.:..|.:.|||       ..:.|||::...
Zfish    11 LPRSASSTRETLENTSSES--SDTEAAEKERSVE-------QRSDDGNADDPK------------ 54

  Fly   262 KRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKM 326
            |:|.:|.||.|:::|:..||..|:|..|||:..||.:|....|.|||::|||.|||||||:.|
Zfish    55 KKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRE-- 117

  Fly   327 RTQRRS-------------ADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERT 378
            |.|:..             ....|....|.|.||          .|:...||..:::.......:
Zfish   118 RNQQMDLCKNSYLPQFSGLMQPYDDVYPTYTYNN----------WTNKGLTPAPLSTKNFTFFNS 172

  Fly   379 SSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAEN 443
            .|.|.|.|:..|.:..:.:...:...|:         |.|.:| .:|.|.:            .|
Zfish   173 MSPLTSQSMFSAPSSISSMSMASGMGHS---------AVPGMP-TTGLNNI------------GN 215

  Fly   444 YNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA-----HQQPPQHGVYTN 503
            .| .:|..|.:........||  ..|:   |||  :.:|:| ||.|.|     .:|.|..|....
Zfish   216 LN-GIGGSTINPAMSSSTCPY--GPPV---SPY--SVYRDT-CNSSLATLRLKSKQHPSFGYSGL 271

  Fly   504 SSPMPSSN 511
            .||..|.|
Zfish   272 QSPGSSLN 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	42/127 (33%)
		Homeobox	269..322	CDD:395001	27/52 (52%)
pitx1	NP_001035436.3	COG5576	8..>126	CDD:227863	48/137 (35%)
		Homeobox	62..114	CDD:278475	26/51 (51%)
		OAR	247..263	CDD:281777	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940