Protein Alignment toy and SHOX2

DIOPT Version :9

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_003021.3
• Gene: SHOX2 / 6474
• HGNCID: 10854
• Length: 355
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 84/353 - (23%)
• Similarity: 118/353 - (33%)
• Gaps: 149/353 - (42%)

  Fly   246 EHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQ 310
            :.::.|.||..   :.|.|.:|:||:|:.||::.||:.|:.|||||.|.||.|:.::||.|||:|
Human   148 KEDAKGMEDEG---QTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQ 209

  Fly   311 VWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVA 375
            |||.|||||.|::|
Human   210 VWFQNRRAKCRKQE--------------------------------------------------- 223

  Fly   376 ERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATM 440
                     |.|.:.     ||.|.|:.......:|.:...|.|:|..
Human   224 ---------NQLHKG-----VLIGAASQFEACRVAPYVNVGALRMPFQ----------------- 257

  Fly   441 AENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSS 505
                ..|..::||...|        ....|.|.|....|||.        .|.....|..|. ..
Human   258 ----QDSHCNVTPLSFQ--------VQAQLQLDSAVAHAHHH--------LHPHLAAHAPYM-MF 301

  Fly   506 PMPSSNTGVISAGVSVPVQISTQNVSDLTGSNYWPRLQXSSIFGSPLDHLS--KATAAAIIAAQA 568
            |.|.                                      ||.||..|:  .|:||:::||.|
Human   302 PAPP--------------------------------------FGLPLATLAADSASAASVVAAAA 328

  Fly   569 AEKSHKHRKEHSIVSIHTTKRKKNPPSL 596
            |.|:..  |..||..:. .|.||:..:|
Human   329 AAKTTS--KNSSIADLR-LKAKKHAAAL 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	38/114 (33%)
		Homeobox	269..322	CDD:395001	31/52 (60%)
SHOX2	NP_003021.3	Homeobox	167..220	CDD:306543	31/52 (60%)
		OAR	335..351	CDD:309087	6/16 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940