DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and LHX5

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_071758.1	Gene:	LHX5 / 64211	HGNCID:	14216	Length:	402	Species:	Homo sapiens

Alignment Length:	348	Identity:	76/348 - (21%)
Similarity:	126/348 - (36%)	Gaps:	117/348 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 ELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTH 288
            :||.:::.....:.:|||   |:..::.:|:.:.....||:  ..||:...:|:::|:..|..|.
Human   144 DLQDALQDDPKETDNSTS---SDKETANNENEEQNSGTKRR--GPRTTIKAKQLETLKAAFAATP 203

  Fly   289 YPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNP----- 348
            .|....||:||.:.||....|||||.|||:|.||.:::        :..|:.|.:...:|
Human   204 KPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQL--------SALGARRHAFFRSPRRMRP 260

  Fly   349 -SGTTASSSVATSNNST-----------PGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEA 401
             .|....|.:..|...|           ||                  ::....::||
Human   261 LGGRLDESEMLGSTPYTYYGDYQGDYYAPG------------------SNYDFFAHGP------- 300

  Fly   402 NTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMF 466
                         |:..:.|.:|.|  :.:|.|.         ::.||::.|.......|....|
Human   301 -------------PSQAQSPADSSF--LAASGPG---------STPLGALEPPLAGPHAADNPRF 341

  Fly   467 HDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSSNTGVISAGVSVPVQISTQNVS 531
            .|.:|         |.:|   ||      |:.|:.....|||..   |.|.|.|.|..:|
Human   342 TDMIS---------HPDT---PS------PEPGLPGTLHPMPGE---VFSGGPSPPFPMS----- 380

  Fly   532 DLTGSNYWPRLQXSSIFGSPLDH 554
                        .:|.:..||.|
Human   381 ------------GTSGYSGPLSH 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	36/131 (27%)
		Homeobox	269..322	CDD:395001	22/52 (42%)
LHX5	NP_071758.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753
		LIM2_Lhx1_Lhx5	64..119	CDD:188761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..186		10/46 (22%)
		Homeobox	183..237	CDD:395001	22/53 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..402		34/163 (21%)
		PHA03378	<301..>392	CDD:223065	32/140 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910