DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment toy and SDCBP

DIOPT Version :9

Sequence 1:NP_001368990.1 Gene:toy / 43833 FlyBaseID:FBgn0019650 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001335270.1 Gene:SDCBP / 6386 HGNCID:10662 Length:319 Species:Homo sapiens


Alignment Length:320 Identity:67/320 - (20%)
Similarity:103/320 - (32%) Gaps:101/320 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 WEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQ--------------------QQNES 169
            |..||..:...|.|    |:..|:...|.:|...|..|||                    ..:.:
Human     5 WTNRDLHIIVMVKN----PAKMSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGN 65

  Fly   170 VYEKLRMFNGQTGGWAWYPSNTTTAHLTLPP----AASVVTSPANLSGQADRDDVQKRELQFSVE 230
            :|.:|            ||..:....|:|..    |...|.|.|.|.||     :..|....:..
Human    66 LYPRL------------YPELSQYMGLSLNEEEIRANVAVVSGAPLQGQ-----LVARPSSINYM 113

  Fly   231 VSHTNSHD------STSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHY 289
            |:....:|      ....|..|.....|:|.::.||||        |..|    .:..:..:.:.
Human   114 VAPVTGNDVGIRRAEIKQGIREVILCKDQDGKIGLRLK--------SIDN----GIFVQLVQANS 166

  Fly   290 PDVFARERLADKIGLPEARIQV-------WFSNRRAKWRRE---EK--MRTQRRSADTVDGSGRT 342
            |......|..|::      :|:       |.|::..|..::   ||  |..:.|..:      ||
Human   167 PASLVGLRFGDQV------LQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFE------RT 219

  Fly   343 STANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEAS----NGPTVLG 398
            .|.:..|  |........|.....||        :.|||..:..|.|.:    ||..|:|
Human   220 ITMHKDS--TGHVGFIFKNGKITSIV--------KDSSAARNGLLTEHNICEINGQNVIG 269

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
toyNP_001368990.1 PAX 29..153 CDD:128645 7/27 (26%)
COG5576 <253..368 CDD:227863 24/126 (19%)
Homeobox 269..322 CDD:395001 9/59 (15%)
SDCBPNP_001335270.1 PDZ_signaling 133..212 CDD:238492 19/96 (20%)
PDZ_signaling 217..290 CDD:238492 17/69 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0849
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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