Protein Alignment toy and pax6b

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_005168876.1
• Gene: pax6b / 60639
• ZFINID: ZDB-GENE-001031-1
• Length: 450
• Species: Danio rerio
• Alignment Length: 557
• Identity: 270/557 - (48%)
• Similarity: 322/557 - (57%)
• Gaps: 136/557 - (24%)

  Fly    10 HGHPHSSVGQSTLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQ-- 72
            |..|....|.:::...|   |||:||||||:||||||||||||||||||||||||||||||||
Zfish     7 HNQPTWESGVASMMQNS---HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTH 68

  Fly    73 -----------VSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWE 126
                       |||||||||||||||||||:|||||||||||||..||.|||.||||||||||||
Zfish    69 DDAKVQLDNKNVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRECPSIFAWE 133

  Fly   127 IRDRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGW----AWY 187
            ||||||||.||.:||||||||||||||||||:|:|...   :.:|:||||.|||:|.|    .||
Zfish   134 IRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGA---DGMYDKLRMLNGQSGTWGTRPGWY 195

  Fly   188 PSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGD 252
            |.                   .::.||.::|..|:::          |..::|:..:|  |....
Zfish   196 PG-------------------TSVPGQPNQDGCQQQD----------NGGENTNSISS--NGEDS 229

  Fly   253 EDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRR 317
            :::||||:||||||||||||:.|||::||||||||||||||||||||.||.||||||||||||||
Zfish   230 DETQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRR 294

  Fly   318 AKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASSSV--ATSNNSTPGIVNSAINVAERTSS 380
            ||||||||:|.|||.|.       .|:::.|..::.::||  |....:||        |:..|.|
Zfish   295 AKWRREEKLRNQRRQAS-------NSSSHIPISSSFNTSVYQAIPQPTTP--------VSFTTGS 344

  Fly   381 ALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYN 445
            .|                |..:|..|                    ||.....|.|..|||.|.
Zfish   345 ML----------------GRPDTALT--------------------NTYTGLPPMPSFTMANNL- 372

  Fly   446 SSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSS 510
                .|.||   |..:|..|..     .||.|:....:|        ..||....:.||..|.:|
Zfish   373 ----PMQPS---QTSSYSCMLP-----SSPSVNGRSFDT--------YTPPHMQAHMNSQTMATS 417

  Fly   511 ---NTGVISAGVSVPVQI-STQNVSDLTGSNYWPRLQ 543
               :||:||.|||||||: .|:  .|:  |.||.|||
Zfish   418 GTASTGLISPGVSVPVQVPGTE--PDM--SQYWSRLQ 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	112/136 (82%)
		COG5576	<253..368	CDD:227863	75/116 (65%)
		Homeodomain	267..322	CDD:459649	48/54 (89%)
pax6b	XP_005168876.1	PAX	23..160	CDD:128645	113/139 (81%)
		Homeodomain	244..299	CDD:459649	48/54 (89%)