Protein Alignment toy and pax8

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_073807835.1
• Gene: pax8 / 60637
• ZFINID: ZDB-GENE-001030-3
• Length: 448
• Species: Danio rerio
• Alignment Length: 576
• Identity: 178/576 - (30%)
• Similarity: 243/576 - (42%)
• Gaps: 192/576 - (33%)

  Fly    29 GHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKP 93
            ||.|:|||||::|||||||:..||:||::||.|.|||||||.|:||:||||||||||||||||||
Zfish     8 GHGGLNQLGGMFVNGRPLPEVIRQRIVDMAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKP 72

  Fly    94 RAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQ 158
            ..||||||:|||..||:|||:|||:.|::||||||||||:|.||:.|.:||||||||::|.
Zfish    73 GVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAEGVCDGDTVPSVSSINRIIRT---- 133

  Fly   159 KEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNT---TTAHLTLPPAASVVTSPANLSGQADRDDV 220
            |.||.             ||        .|.:|   :..|..:|  :|.||.|.  |.|:|
Zfish   134 KVQQP-------------FN--------LPLDTKGLSPGHTLIP--SSAVTPPE--SPQSD---- 169

  Fly   221 QKRELQFSVEVSHTNS-------HDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQID 278
                     .:..|.|       ..:|:||...|:.|..|..:                  ..:|
Zfish   170 ---------SLGSTYSINGLLGITQTTADGKRGHDDSDQESCR------------------HSVD 207

  Fly   279 S------LEKEFERTHYPDV-----FARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRS 332
            |      ..|:....|:|..     |.|...:|.....:|..|::            .:......
Zfish   208 SQGSGGGARKQLRTEHFPSAALDCGFERHYSSDSFSQSKAEQQLY------------PLALMNPG 260

  Fly   333 ADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVL 397
            .|  :|.|.:|.:.|.:.....:.|..:....|..:...::..        .|||   |..|.::
Zfish   261 LD--EGKGASSISRNLAAHQGYAVVTEALQPLPLCLKQEVSPE--------GNSL---SPSPNII 312

  Fly   398 GGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAY 462
            .|.|....::..||...|.|                            ||.||
Zfish   313 SGSAFLDLSTISSPSSAPVA----------------------------SSCGS------------ 337

  Fly   463 PYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPM-----------------PSS 510
            .::.|...|.      :||             .|.||.:::.|.|                 |::
Zfish   338 AHLSHGFSSF------SHH-------------APVHGQFSSPSLMAGREVASSMLPGYPPHIPTA 383

  Fly   511 NTG----VISAGVSVPVQISTQNVSDLTGSNY---WPRLQXSSIFGSPLDHLSKAT 559
            .||    .|:..||.| :.:.|:.|....|:|   | |.. |||.|||. :.|.||
Zfish   384 QTGFSSSTIAGMVSAP-EYTGQSYSHPAYSSYSEAW-RFTNSSILGSPY-YYSSAT 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	90/123 (73%)
		COG5576	<253..368	CDD:227863	18/125 (14%)
		Homeodomain	267..322	CDD:459649	10/65 (15%)
pax8	XP_073807835.1	None