Protein Alignment toy and otx2

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_012823826.1
• Gene: otx2 / 548931
• XenbaseID: XB-GENE-485220
• Length: 306
• Species: Xenopus tropicalis
• Alignment Length: 229
• Identity: 79/229 - (34%)
• Similarity: 115/229 - (50%)
• Gaps: 34/229 - (14%)

  Fly   263 RKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREE--- 324
            ||.:|.||:|:..|:|.||..|.:|.|||:|.||.:|.||.|||:|:||||.|||||.|:::
 Frog    53 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQ 117

  Fly   325 ------KMRTQRRS---ADTVDGSGRTSTANNPSGTTA----SSSVATSNNSTPGIVNSAINVAE 376
                  |:|..::.   |..|.....||...:|..:|:    |||.|..:..:|..: |.::...
 Frog   118 QNGGQNKVRPSKKKPSPAREVSSESGTSGQFSPPCSTSVPVISSSTAPVSIWSPASI-SPLSDPL 181

  Fly   377 RTSSALVSNSLP----EASN------GPT-VLGGEANTTHTSSESPPLQPAAPRL-PLNSGFNTM 429
            .|||:.:..|.|    :||.      |.| ..||....::.:.....|..|...| |:  |.|.:
 Frog   182 STSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLSGAGATLSPM--GTNAV 244

  Fly   430 YSSIPQ-PIATMAENYN-SSLG-SMTPSCLQQRD 460
            .|.:.| |.|..::.|. |||| :.|..||..:|
 Frog   245 TSHLNQSPAALSSQAYGASSLGFNSTADCLDYKD 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	48/120 (40%)
		Homeodomain	267..322	CDD:459649	32/54 (59%)
otx2	XP_012823826.1	Homeodomain	56..111	CDD:459649	32/54 (59%)
		TF_Otx	170..251	CDD:427350	20/83 (24%)