DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and hoxb3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001015971.1	Gene:	hoxb3 / 548725	XenbaseID:	XB-GENE-482576	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	415	Identity:	87/415 - (20%)
Similarity:	148/415 - (35%)	Gaps:	132/415 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 QNESVYEKLRMFNG---QTGGWAW---YPSNTTTAHL------------TLPPAASVVTSPANLS 212
            |..|.|:...:|.|   |.|...:   ..|..|::|:            :|..:..:|.: .||:
Frog     2 QKASYYDNPTLFGGYPYQAGSLGYEGPQQSFPTSSHMDNEFQRSSCSLQSLGHSGPLVKA-KNLN 65

  Fly   213 GQADRDDVQKRELQ----FSVEVSHTNSHDS----TSDGNSEHNSSGDEDS--------QMRLRL 261
            |...|.::...:.|    .:...|:|||..|    :....::..:||...|        :.|...
Frog    66 GSCMRPNLSSEQSQPLSPTANPSSNTNSSSSQASLSKPSPAKSQASGSPASKQIFPWMKESRQNS 130

  Fly   262 KRK----------------------LQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGL 304
            |:|                      .:|.||::::.|:..|||||....|.....|..:|:.:.|
Frog   131 KQKSSPPAPAAESCGGDRSPPGSSASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNL 195

  Fly   305 PEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVN 369
            .|.:|::||.|||.|:::::|::            |.:|::   .|.:.:|:...|..|:.|.:.
Frog   196 SERQIKIWFQNRRMKYKKDQKVK------------GMSSSS---GGASPTSTPPLSMQSSAGFLG 245

  Fly   370 SAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIP 434
            |.                            .:.|.:..:.|||        |.|......|...|
Frog   246 SM----------------------------HSMTANYEAPSPP--------PFNKSHQNAYYQNP 274

  Fly   435 QPIATMAENYNSSLGSMTPSCLQ-QRDAY--PYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPP 496
            .......:.|.::........|| ...||  |.|...|:.:|..||.          |...|.||
Frog   275 GKGCPSQQKYGNTAAEYDHHGLQGNGGAYVSPNMQGSPVYVGGNYVD----------SVPAQGPP 329

  Fly   497 QHGV-----------YTNSSPMPSS 510
            .:|:           |..:.|||:|
Frog   330 LYGLNHLAHQPTNMDYNGAPPMPAS 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	33/144 (23%)
		Homeobox	269..322	CDD:395001	20/52 (38%)
hoxb3	NP_001015971.1	Homeobox	160..212	CDD:306543	20/51 (39%)
hoxb3	NP_001015971.1	DUF4074	325..384	CDD:315871	9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910