DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and pdlim5

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_012817118.2	Gene:	pdlim5 / 548530	XenbaseID:	XB-GENE-854114	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	641	Identity:	133/641 - (20%)
Similarity:	220/641 - (34%)	Gaps:	180/641 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PRAIGGSKPRVATTPVVQKIADYK-RECPSIFAWEIRDRLLSEQVCNSDNIPSVSS-INRVLRNL 155
            |:.|....|..:.|||..|:::.. .:.|..|.        |.......:|||.|| ......:|
Frog   100 PKEIIKPVPIASPTPVAPKVSNVAYNKAPKPFG--------SATSSKPASIPSASSAFTPASASL 156

  Fly   156 ASQKEQQAQQQNESVYEKLRMF----NGQTGGWAWYPSNTTTAHLTLP------PAASVVTSPAN 210
            :.|...|     .|....|...    |...|   .:.::.||....||      ||.:|...||:
Frog   157 SIQSSPQ-----PSALSLLAQVGPPPNSAPG---LHANSKTTIEGHLPALSATKPAVNVPRQPAS 213

  Fly   211 LSGQADRDDVQKRELQFSVEVSHTNSHDSTSDG----NSEHNSSGDEDSQMRLRLKRKLQRNRTS 271
            .|..|:..|                 ::...||    ..:..:.||:....::..||..:::
Frog   214 YSQTANLYD-----------------NEVAQDGAEVRRGQKENQGDKHQNGKIPPKRPPRKH--- 258

  Fly   272 FSNEQIDSLEKEFERTHYPDVFARERLAD-------KIGLPEAR-----IQVWFSNRRAKWRREE 324
                .:|:....:..:.|.|. :::||.|       :.|..::|     .|:..:...::...|.
Frog   259 ----IVDTYTDIYHTSAYSDA-SKKRLIDNTEDWHPRTGTTQSRSFRILAQMTGTEHMSEPEPEN 318

  Fly   325 KMRTQRRSADTVDGSGRTSTANNPSG--------TTASSSVATSNNSTPGIVNSAINVAERTSSA 381
            ..:|  :.::..:|...|| |.:|:|        ...:.||||..:.....|...::::||...|
Frog   319 VQKT--KESNICNGDISTS-AESPNGREDRKLSQNAEACSVATQTDVPVEDVTLILDLSERPEPA 380

  Fly   382 LVSNS----LPEASNGPTVLGGEANTTHTS-SESP------------------PLQPAAPR-LPL 422
            |:...    :......|     |.:...|| |:||                  |..||..: |.:
Frog   381 LLEREETYFVSSCRTSP-----EKSAVQTSPSQSPHRRKSLFDNPLESLPKAAPFPPATVQILKV 440

  Fly   423 NSGFNT--------MYSSIPQPIATMAENYNSSL----GSMTPSCLQQRDAYPYMFHDPLSLGSP 475
            ||...|        |.||:..| .::.||.:|:.    |:.|....:::.:......|.:.:.:.
Frog   441 NSQVATIAKTASVYMRSSMVIP-DSLLENSSSAATVINGTGTKINAKEKCSIATQTCDKVLIPAS 504

  Fly   476 YVSAHHRNTACNPSAAHQQPPQHGVYTN-------SSPMPSSNTGVISAGVSVPVQIST------ 527
            ...|.....:..||.. |.||:..:..|       .:|.|..        |..|:.|.|
Frog   505 SPCAVEYIASVIPSTP-QVPPRQYIAANPLDTLPKCAPCPPP--------VLAPLTIQTCKSKVS 560

  Fly   528 --QNVSDLTGSNYWPRLQXSSIFGSPLDHL--SKATAAAIIAAQAAEKS-------HKHRKEHSI 581
              ..|:.:.|:.  .||. ..:..|.||.|  |....::...::...||       |    .||.
Frog   561 AVAAVTAIVGAQ--ARLSDPFVSRSLLDALLISPIPKSSFPTSKPTRKSTGGLYTGH----NHSN 619

  Fly   582 VSIH-----TTKRK------KNPPSLKR--------QTTCCSSRYLNMTFGAGKDV 618
            ||:.     .|..|      |:|||.|.        ||...|.:..|....|.|.|
Frog   620 VSVEVPPATATSSKIMPSSYKSPPSSKPVTSKPTGWQTVPSSGQVTNNASNAVKPV 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	15/61 (25%)
		COG5576	<253..368	CDD:227863	23/134 (17%)
		Homeobox	269..322	CDD:395001	9/64 (14%)
pdlim5	XP_012817118.2	PDZ	10..83	CDD:214570
		PRK14951	<80..216	CDD:237865	31/131 (24%)
		DUF4749	212..320	CDD:406377	20/132 (15%)
		LIM1_ENH	708..759	CDD:188837
		LIM2_Enigma_like	767..818	CDD:188748
		LIM3_ENH	826..880	CDD:188843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030