DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and PITX3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_005020.1	Gene:	PITX3 / 5309	HGNCID:	9006	Length:	302	Species:	Homo sapiens

Alignment Length:	329	Identity:	91/329 - (27%)
Similarity:	129/329 - (39%)	Gaps:	87/329 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 STSDGNS------EHNSSGDEDSQMRL-------------RLKRKLQRNRTSFSNEQIDSLEKEF 284
            |.||..:      ||...|.|.|....             .||:|.:|.||.|:::|:..||..|
Human    17 SLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATF 81

  Fly   285 ERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRT------- 342
            :|..|||:..||.:|....|.|||::|||.|||||||:.|  |:|:  |:...||...
Human    82 QRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRE--RSQQ--AELCKGSFAAPLGGLVP 142

  Fly   343 ---------STANNPSGTTASSSVATSNNSTPGIVNSAINVAERTS-------SALVSNSLPEAS 391
                     |..|.|....|....|   .:.|...|| :||....|       |::.::.:|.|:
Human   143 PYEEVYPGYSYGNWPPKALAPPLAA---KTFPFAFNS-VNVGPLASQPVFSPPSSIAASMVPSAA 203

  Fly   392 NGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCL 456
            ..|..:.|...........|.|.|||    ::||      ::..|.|:.|....::..|
Human   204 AAPGTVPGPGALQGLGGGPPGLAPAA----VSSG------AVSCPYASAAAAAAAAASS------ 252

  Fly   457 QQRDAYPYMFHDPL--SLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSSNTGVISAGV 519
                  ||::.||.  ||.|..:.|...       |:...|..||      |.|::|.......|
Human   253 ------PYVYRDPCNSSLASLRLKAKQH-------ASFSYPAVHG------PPPAANLSPCQYAV 298

  Fly   520 SVPV 523
            ..||
Human   299 ERPV 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	46/143 (32%)
		Homeobox	269..322	CDD:395001	27/52 (52%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		15/53 (28%)
		Homeobox	66..119	CDD:395001	27/52 (52%)
		OAR	258..275	CDD:397759	6/23 (26%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	262..275		4/19 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940