DRSC/TRiP Functional Genomics Resources

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Protein Alignment toy and PITX1

DIOPT Version :9

Sequence 1:NP_001368990.1 Gene:toy / 43833 FlyBaseID:FBgn0019650 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_002644.4 Gene:PITX1 / 5307 HGNCID:9004 Length:314 Species:Homo sapiens


Alignment Length:333 Identity:94/333 - (28%)
Similarity:131/333 - (39%) Gaps:87/333 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   199 PPAASVVTSPA-NLSGQADRDDVQKRELQFSVEVSHTNSHDS-------------TSDGNSEHNS 249
            ||.......|| :|:..||     .||   .:|.|.:.|.|:             ..|..:....
Human    20 PPPPPHDMGPAFHLARPAD-----PRE---PLENSASESSDTELPEKERGGEPKGPEDSGAGGTG 76

  Fly   250 SGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFS 314
            .|..|...:   |:|.:|.||.|:::|:..||..|:|..|||:..||.:|....|.|.|::|||.
Human    77 CGGADDPAK---KKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFK 138

  Fly   315 NRRAKWRREEKMRTQRRSADTVDG------SGRTS------TANNPSGTTASSSVATSNNSTPGI 367
            |||||||:.|:    .:..|...|      ||...      .|.......|:.|:|.:..||...
Human   139 NRRAKWRKRER----NQQLDLCKGGYVPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSF 199

  Fly   368 V--NSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMY 430
            .  ||        .|.|.|.|:..|   |:.:   ::.|..||..|...|..|    |||.|   
Human   200 TFFNS--------MSPLSSQSMFSA---PSSI---SSMTMPSSMGPGAVPGMP----NSGLN--- 243

  Fly   431 SSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA--HQ 493
                        |.|:..||...|.:.. .|.||.     :..|||  :.:|:| ||.|.|  ..
Human   244 ------------NINNLTGSSLNSAMSP-GACPYG-----TPASPY--SVYRDT-CNSSLASLRL 287

  Fly   494 QPPQHGVY 501
            :..||..:
Human   288 KSKQHSSF 295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
toyNP_001368990.1 PAX 29..153 CDD:128645
COG5576 <253..368 CDD:227863 42/126 (33%)
Homeobox 269..322 CDD:395001 26/52 (50%)
PITX1NP_002644.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..103 23/93 (25%)
COG5576 36..>146 CDD:227863 40/120 (33%)
Homeobox 93..146 CDD:395001 26/52 (50%)
Interaction with PIT-1. /evidence=ECO:0000250 147..279 42/177 (24%)
OAR 276..293 CDD:397759 6/17 (35%)
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 280..293 3/12 (25%)
Nuclear localization signal. /evidence=ECO:0000255 286..290 0/3 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6207
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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