DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and PAX9

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001359005.1	Gene:	PAX9 / 5083	HGNCID:	8623	Length:	341	Species:	Homo sapiens

Alignment Length:	268	Identity:	113/268 - (42%)
Similarity:	146/268 - (54%)	Gaps:	47/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 INQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIG 97
            :||||||:|||||||::.|.:|||||..|.|||||||.|:||:|||||||.||.|||||.|.|||
Human     8 VNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIG 72

  Fly    98 GSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLR----NLASQ 158
            ||||||.|..||:.|..||:..|.|||||||||||::.||:..|:||||||:|:||    |||.|
Human    73 GSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQ 137

  Fly   159 KEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKR 223
            ....:.:|::...:....:|....    |||..|.|...:|....|...|.
Human   138 GHYDSYKQHQPTPQPALPYNHIYS----YPSPITAAAAKVPTPPGVPAIPG-------------- 184

  Fly   224 ELQFSVEVSHT--NSH------------DSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSN 274
                ||.:..|  :||            |..||.:..|:...:|.|.:.       :.|..:.:.
Human   185 ----SVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLG-------RNNFPAAAP 238

  Fly   275 EQIDSLEK 282
            ..::.|||
Human   239 HAVNGLEK 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	82/119 (69%)
		COG5576	<253..368	CDD:227863	6/30 (20%)
		Homeobox	269..322	CDD:395001	3/14 (21%)
PAX9	NP_001359005.1	PAX	6..131	CDD:238076	84/122 (69%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	7..63		39/54 (72%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	82..130		29/47 (62%)
		Interaction with KDM5B. /evidence=ECO:0000269\|PubMed:12657635	168..189		6/38 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910