Protein Alignment toy and PAX9

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_006185.1
• Gene: PAX9 / 5083
• HGNCID: 8623
• Length: 341
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 113/268 - (42%)
• Similarity: 146/268 - (54%)
• Gaps: 47/268 - (17%)

  Fly    33 INQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIG 97
            :||||||:|||||||::.|.:|||||..|.|||||||.|:||:|||||||.||.|||||.|.|||
Human     8 VNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIG 72

  Fly    98 GSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLR----NLASQ 158
            ||||||.|..||:.|..||:..|.|||||||||||::.||:..|:||||||:|:||    |||.|
Human    73 GSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQ 137

  Fly   159 KEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKR 223
            ....:.:|::...:....:|....    |||..|.|...:|....|...|.
Human   138 GHYDSYKQHQPTPQPALPYNHIYS----YPSPITAAAAKVPTPPGVPAIPG-------------- 184

  Fly   224 ELQFSVEVSHT--NSH------------DSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSN 274
                ||.:..|  :||            |..||.:..|:...:|.|.:.       :.|..:.:.
Human   185 ----SVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLG-------RNNFPAAAP 238

  Fly   275 EQIDSLEK 282
            ..::.|||
Human   239 HAVNGLEK 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	82/119 (69%)
		COG5576	<253..368	CDD:227863	6/30 (20%)
		Homeodomain	267..322	CDD:459649	4/16 (25%)
PAX9	NP_006185.1	PAX	6..131	CDD:238076	84/122 (69%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	7..63		39/54 (72%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	82..130		29/47 (62%)
		Interaction with KDM5B. /evidence=ECO:0000269|PubMed:12657635	168..189		6/38 (16%)