Protein Alignment toy and PAX6

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 273/531 - (51%)
• Similarity: 317/531 - (59%)
• Gaps: 124/531 - (23%)

  Fly    27 TAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSI 91
            |.||||:||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Human    83 TGGHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSI 147

  Fly    92 KPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLA 156
            :|||||||||||||..||.|||.||||||||||||||||||||.||.:|||||||||||||||||
Human   148 RPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLA 212

  Fly   157 SQKEQQAQQQNESVYEKLRMFNGQTGGW----AWYPSNTTTAHLTLPPAASVVTSPANLSGQADR 217
            |:|:|...   :.:|:||||.|||||.|    .|||.                   .::.||..:
Human   213 SEKQQMGA---DGMYDKLRMLNGQTGSWGTRPGWYPG-------------------TSVPGQPTQ 255

  Fly   218 DDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEK 282
            |..|::|    ....:|||..|        |....:::||||:||||||||||||:.|||::|||
Human   256 DGCQQQE----GGGENTNSISS--------NGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEK 308

  Fly   283 EFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANN 347
            |||||||||||||||||.||.||||||||||||||||||||||:|.|||.|           :|.
Human   309 EFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQA-----------SNT 362

  Fly   348 PSGTTASSSVATS------NNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHT 406
            ||....|||.:||      ..:||        |:..||.:::               |..:|..|
Human   363 PSHIPISSSFSTSVYQPIPQPTTP--------VSSFTSGSML---------------GRTDTALT 404

  Fly   407 SSESPPLQPAAPRLPLNSGFNTMYSSI-PQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPL 470
            ::                     ||:: |.|..|||.|.     .|.|....|..:|..|...
Human   405 NT---------------------YSALPPMPSFTMANNL-----PMQPPVPSQTSSYSCMLPT-- 441

  Fly   471 SLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSS---NTGVISAGVSVPVQISTQNVSD 532
               ||.|:....:|        ..||....:.||.||.:|   :||:||.|||||||:..   |:
Human   442 ---SPSVNGRSYDT--------YTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPG---SE 492

  Fly   533 LTGSNYWPRLQ 543
            ...|.||||||
Human   493 PDMSQYWPRLQ 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	113/123 (92%)
		COG5576	<253..368	CDD:227863	78/120 (65%)
		Homeodomain	267..322	CDD:459649	48/54 (89%)
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	113/123 (92%)
		Homeodomain	293..348	CDD:459649	48/54 (89%)