Protein Alignment toy and PAX5

DIOPT Version :9

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_057953.1
• Gene: PAX5 / 5079
• HGNCID: 8619
• Length: 391
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 169/486 - (34%)
• Similarity: 224/486 - (46%)
• Gaps: 133/486 - (27%)

  Fly    26 STAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGS 90
            |..||.|:||||||:||||||||..||:||||||.|.|||||||.|:||:|||||||||||||||
Human    13 SRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGS 77

  Fly    91 IKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNL 155
            |||..||||||:|||..||:|||:|||:.|::||||||||||:|:||::|.:||||||||::|..
Human    78 IKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTK 142

  Fly   156 ASQ-KEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASV--------VTSPANL 211
            ..| ..|.....:.|:.        .||      |.|..:.::...|.|.        :|||:
Human   143 VQQPPNQPVPASSHSIV--------STG------SVTQVSSVSTDSAGSSYSISGILGITSPS-- 191

  Fly   212 SGQADRDDVQKRELQFSVEVSHT-NSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNE 275
                  .|..||:....::.|.. |.|.............||                  .|:.:
Human   192 ------ADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGD------------------LFTQQ 232

  Fly   276 QIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSG 340
            |::.|::.|||.||.|:|.
Human   233 QLEVLDRVFERQHYSDIFT---------------------------------------------- 251

  Fly   341 RTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTH 405
             |:....|..||..|::|   :...|:.:...|:|..| .|.:.:|:|...:.|.|.|.:..:|.
Human   252 -TTEPIKPEQTTEYSAMA---SLAGGLDDMKANLASPT-PADIGSSVPGPQSYPIVTGRDLASTT 311

  Fly   406 TSSESPPLQPA------APRL----PLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRD 460
            .....|.:.||      ||.|    | .|.|:....|.||     ..:||.|
Human   312 LPGYPPHVPPAGQGSYSAPTLTGMVP-GSEFSGSPYSHPQ-----YSSYNDS------------- 357

  Fly   461 AYPYMFHDPLSLGSPYVSAHHRNTACNPSAA 491
               :.|.:|..|||||..:.....|..|:||
Human   358 ---WRFPNPGLLGSPYYYSAAARGAAPPAAA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	94/123 (76%)
		COG5576	<253..368	CDD:227863	17/114 (15%)
		Homeobox	269..322	CDD:395001	10/52 (19%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		4/7 (57%)
		PAX	16..140	CDD:128645	94/123 (76%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		32/47 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..218		9/43 (21%)
		Pax2_C	279..389	CDD:403565	36/130 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910