DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and PAX1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_006183.2	Gene:	PAX1 / 5075	HGNCID:	8615	Length:	534	Species:	Homo sapiens

Alignment Length:	482	Identity:	146/482 - (30%)
Similarity:	192/482 - (39%)	Gaps:	170/482 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GHPHSSVGQSTLFGCSTAGHSG----------------INQLGGVYVNGRPLPDSTRQKIVELAH 59
            |||               ||.|                :||||||:|||||||::.|.:|||||.
Human    79 GHP---------------GHPGARQLAGPLAMEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQ 128

  Fly    60 SGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFA 124
            .|.|||||||.|:||:|||||||.||.|||||.|.|||||||||.|..||:.|.|||:..|.|||
Human   129 LGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFA 193

  Fly   125 WEIRDRLLSEQVCNSDNIPSVSSINRVLRN----LASQKEQQAQQQNES----VYEKLRMFNGQT 181
            ||||||||::.||:..|:||||||:|:|||    ||.....:|.:|..|    .|..:..:.
Human   194 WEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQPPSQPTLPYNHIYQYP--- 255

  Fly   182 GGWAWYPSNT---------------TTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEV 231
                 |||..               |..|:::|.:.....|.:|:.|             ....:
Human   256 -----YPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILG-------------IRTFM 302

  Fly   232 SHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSF-SNEQIDSLEKEFERTHYPDVFAR 295
            ..|.:            .:|.|.:....:::.....|||:| :...::.|||
Human   303 EQTGA------------LAGSEGTAYSPKMEDWAGVNRTAFPATPAVNGLEK------------- 342

  Fly   296 ERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASSSVATS 360
                     |.....:.::                :||.|:...|         |...:.:...|
Human   343 ---------PALEADIKYT----------------QSASTLSAVG---------GFLPACAYPAS 373

  Fly   361 NN----STPGIVNSAINVAERTSSALVSNSLPEASNGP---------TVLGGEANTT----HTSS 408
            |.    |.||            ...|........:.||         .|.|||....    |.|.
Human   374 NQHGVYSAPG------------GGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELAAAMTFKHPSR 426

  Fly   409 E-SPPLQPAAPRLPLNSGFNTMYSSIP 434
            | |.|...|.||.|     :..|:..|
Human   427 EGSLPAPAARPRTP-----SVAYTDCP 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	86/139 (62%)
		COG5576	<253..368	CDD:227863	19/119 (16%)
		Homeobox	269..322	CDD:395001	7/53 (13%)
PAX1	NP_006183.2	PAX	98..225	CDD:238076	86/126 (68%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	101..157		39/55 (71%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	176..224		30/47 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..480		10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910