Protein Alignment toy and DUXA

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001012747.1
• Gene: DUXA / 503835
• HGNCID: 32179
• Length: 204
• Species: Homo sapiens
• Alignment Length: 178
• Identity: 50/178 - (28%)
• Similarity: 79/178 - (44%)
• Gaps: 30/178 - (16%)

  Fly   187 YPSNTTTAHLTLPPAASVVTSPANL----SGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEH 247
            ||...|...|.|    .:.|..:.:    ..:..|...|||....::|.|.:...|..   ..|.
Human    39 YPGYATKQKLAL----EINTEESRIQIWFQNRRARHGFQKRPEAETLESSQSQGQDQP---GVEF 96

  Fly   248 NSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVW 312
            .|             |:.:|.||::|..|:.:|.|.|.:..||.:.:||.||.:||:||:|:|:|
Human    97 QS-------------REARRCRTTYSASQLHTLIKAFMKNPYPGIDSREELAKEIGVPESRVQIW 148

  Fly   313 FSNRRAK---WRREEKMRT--QRRSADTVDG-SGRTSTANNPSGTTAS 354
            |.|||::   .|:.|.:.:  |.......:| .|...|.|..:.|:.|
Human   149 FQNRRSRLLLQRKREPVASLEQEEQGKIPEGLQGAEDTQNGTNFTSDS 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	35/108 (32%)
		Homeodomain	267..322	CDD:459649	25/57 (44%)
DUXA	NP_001012747.1	homeodomain	16..74	CDD:238039	7/38 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..101		9/43 (21%)
		Homeodomain	102..155	CDD:459649	25/52 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..204		8/34 (24%)