Protein Alignment toy and OTX1

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 84/270 - (31%)
• Similarity: 126/270 - (46%)
• Gaps: 50/270 - (18%)

  Fly   263 RKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEK-- 325
            ||.:|.||:|:..|:|.||..|.:|.|||:|.||.:|.||.|||:|:||||.|||||.|::::
Human    36 RKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSG 100

  Fly   326 MRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEA 390
            ..|:.|.|.......|.|:.:..||.....:|::|.:|:....:|:.|.|...::.|..|.:..|
Human   101 SGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAA 165

  Fly   391 SNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSC 455
            |:..|  ...::....:|.||...||:             .|:|:|:|..:..          ||
Human   166 SSLST--PAASSIWSPASISPGSAPAS-------------VSVPEPLAAPSNT----------SC 205

  Fly   456 LQQRDA---------YPYMFHDPLSLGSPY---VSAHHRNTACN----PSAAHQQPPQHGVYTNS 504
            :|:..|         ||..:....|.|..|   .|::.....|:    |..:|..|.|      .
Human   206 MQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQ------L 264

  Fly   505 SPM-PSSNTG 513
            ||| |||..|
Human   265 SPMAPSSMAG 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	45/106 (42%)
		Homeodomain	267..322	CDD:459649	32/54 (59%)
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		13/54 (24%)
		TF_Otx	178..274	CDD:427350	30/124 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		10/24 (42%)