DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and pitx1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001007500.1	Gene:	pitx1 / 493226	XenbaseID:	XB-GENE-485441	Length:	305	Species:	Xenopus tropicalis

Alignment Length:	334	Identity:	95/334 - (28%)
Similarity:	138/334 - (41%)	Gaps:	78/334 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 PANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSE------------HNSSGDEDSQMRLR 260
            |.:|..|...|......||.|.|......:.::...::|            .:.:||:.::
Frog    14 PESLRPQPSHDMATSFHLQRSSEARDPMDNSASESSDTEIAEKERSGEPKGEDGNGDDPTK---- 74

  Fly   261 LKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEK 325
             |:|.:|.||.|:::|:..||..|:|..|||:..||.:|....|.|||::|||.|||||||:.|
Frog    75 -KKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEARVRVWFKNRRAKWRKRE- 137

  Fly   326 MRTQR----RSADTVDGSGRTST-----ANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSA 381
             |.|:    ::......||....     |..|....|:.|:      ||..::        |.|.
Frog   138 -RNQQMDLCKNGYVPQFSGLMQPYDEMYAGYPYNNWATKSL------TPAPLS--------TKSF 187

  Fly   382 LVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYN- 445
            ...||:...|: .::..|.::.:..|..|.....|.|.:| ||..|.:            .|.|
Frog   188 TFFNSMSPLSS-QSMFSGPSSISSMSMPSSMGHSAVPGMP-NSSLNNI------------NNLNN 238

  Fly   446 ---SSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA--HQQPPQHGVYTNS- 504
               |||.|...|     .|.||  ..|   ||||..  :|:| ||.|.|  ..:..||..:..|
Frog   239 ISSSSLNSAMSS-----TACPY--GPP---GSPYTV--YRDT-CNSSLASLRLKSKQHSTFGYSS 290

  Fly   505 --SPMPSSN 511
              ||..|.|
Frog   291 LQSPASSLN 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	42/123 (34%)
		Homeobox	269..322	CDD:395001	27/52 (52%)
pitx1	NP_001007500.1	Homeobox	82..135	CDD:365835	27/52 (52%)
pitx1	NP_001007500.1	OAR	267..285	CDD:367680	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030