Protein Alignment toy and pax6

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_031755865.1
• Gene: pax6 / 448447
• XenbaseID: XB-GENE-484088
• Length: 469
• Species: Xenopus tropicalis
• Alignment Length: 542
• Identity: 272/542 - (50%)
• Similarity: 314/542 - (57%)
• Gaps: 136/542 - (25%)

  Fly    30 HSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQ--------------VSNGCVSK 80
            |||:||||||:||||||||||||||||||||||||||||||||              ||||||||
 Frog    36 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQSHADAKVPVLDSQNVSNGCVSK 100

  Fly    81 ILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSV 145
            |||||||||||:|||||||||||||..||.|||.||||||||||||||||||||.||.:||||||
 Frog   101 ILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV 165

  Fly   146 SSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGW----AWYPSNTTTAHLTLPPAASVVT 206
            ||||||||||||:|:|...   :.:|:||||.|||||.|    .|||.
 Frog   166 SSINRVLRNLASEKQQMGA---DGMYDKLRMLNGQTGTWGTRPGWYPG----------------- 210

  Fly   207 SPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTS 271
              .::.||..:|..|.:|.....|  :|||..|        |....:::||||:|||||||||||
 Frog   211 --TSVPGQPAQDGCQPQEGGGGGE--NTNSISS--------NGEDSDEAQMRLQLKRKLQRNRTS 263

  Fly   272 FSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTV 336
            |:.|||::||||||||||||||||||||.||.||||||||||||||||||||||:|.|||.|
 Frog   264 FTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQA--- 325

  Fly   337 DGSGRTSTANNPSGTTASSSVATS------NNSTPGIVNSAINVAERTSSALVSNSLPEASNGPT 395
                    :|.||....|||.:||      ..:||        |:..||.:::
 Frog   326 --------SNTPSHIPISSSFSTSVYQPIPQPTTP--------VSSFTSGSML------------ 362

  Fly   396 VLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSI-PQPIATMAENYNSSLGSMTPSCLQQR 459
               |..:|..|:|                     ||:: |.|..||..|.     .|.|....|.
 Frog   363 ---GRTDTALTNS---------------------YSALPPMPSFTMGNNL-----PMQPPVPSQT 398

  Fly   460 DAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSS---NTGVISAGVSV 521
            .:|..|...     ||.|:....:|        ..||....:.||.||.:|   :||:||.||||
 Frog   399 SSYSCMLPT-----SPSVNGRSYDT--------YTPPHMQTHMNSQPMGTSGTASTGLISPGVSV 450

  Fly   522 PVQISTQNVSDLTGSNYWPRLQ 543
            |||:..   |:...|.||||||
 Frog   451 PVQVPG---SEPDMSQYWPRLQ 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	112/136 (82%)
		COG5576	<253..368	CDD:227863	78/120 (65%)
		Homeodomain	267..322	CDD:459649	48/54 (89%)
pax6	XP_031755865.1	PAX	35..173	CDD:128645	112/136 (82%)
		Homeodomain	259..314	CDD:459649	48/54 (89%)