DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and pitx3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_991238.1	Gene:	pitx3 / 402974	ZFINID:	ZDB-GENE-041229-4	Length:	293	Species:	Danio rerio

Alignment Length:	295	Identity:	88/295 - (29%)
Similarity:	130/295 - (44%)	Gaps:	56/295 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 DVQKRELQFSVEVSHTNSHD------STSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQI 277
            |.:.|....|:..|.|..||      ..||....|.:..||.:.....||:|.:|.||.|:::|:
Zfish     8 DSEARSPALSLSDSGTPQHDPGCKGQDNSDTEKSHQNHTDESNPEDGSLKKKQRRQRTHFTSQQL 72

  Fly   278 DSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGR- 341
            ..||..|:|..|||:..||.:|....|.|||::|||.|||||||:.|:   .:::....:|.|.
Zfish    73 QELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER---NQQAELCKNGFGAQ 134

  Fly   342 ------------TSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVS--NSLPE--- 389
                        :..:.|...|.:.:|...|..|.| ..|| :||:..:|..:.|  :|:|.
Zfish   135 FNGLMQPYDDMYSGYSYNNWATKSLASSPLSAKSFP-FFNS-MNVSPLSSQPMFSPPSSIPSMNM 197

  Fly   390 -ASNGPTVLGGEANT------THTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENY--- 444
             :|..|:.:.|...:      ...:..||.|..||            .|:...|.||.|..|
Zfish   198 ASSMVPSAVAGVPGSGLNNLGNLNNLNSPTLNSAA------------VSAAACPYATTAGPYMYR 250

  Fly   445 ---NSSLGSMTPSCLQQRD-AYPYMFHDPLSLGSP 475
               ||||.|:.....|..: |||.: .:|:|..||
Zfish   251 DTCNSSLASLRLKAKQHANFAYPAV-QNPVSNLSP 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	42/127 (33%)
		Homeobox	269..322	CDD:395001	27/52 (52%)
pitx3	NP_991238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		19/60 (32%)
		Cnd2	18..>79	CDD:303063	19/60 (32%)
		Homeobox	64..116	CDD:278475	26/51 (51%)
		OAR	251..268	CDD:281777	6/16 (38%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	255..268		5/12 (42%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O35160	260..264		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940