DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and Zasp52

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	117/544 - (21%)
Similarity:	179/544 - (32%)	Gaps:	140/544 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDI--------------SRILQVSN 75
            ||.......|:|     |..|.||.||...     .|..|..:              |.||.||.
  Fly  1539 CSATHARNYNEL-----NASPFPDRTRSPA-----PGPPPNPLNAIRAPRMKEPETKSNILSVSG 1593

  Fly    76 GCVSKILGRYYETGSIKPRAIGGSKPRVATTPVV-------QKIADYKRECPSIF-AWEIRDRLL 132
            |                        ||:.|..:.       |.:|..::...|.. ::..:...:
  Fly  1594 G------------------------PRLQTGSITTGQSYQGQLLAHSEQSSQSASQSYNQQPERI 1634

  Fly   133 SEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLT 197
            :||        .|.::|...|..:||.:||||.|.:|      ....|.|..........|....
  Fly  1635 TEQ--------RVGNLNIQQREQSSQLQQQAQSQTQS------QTRSQVGNTQIERRRKVTEEFE 1685

  Fly   198 LPPAASVVTSPANLSGQADRDDVQKREL-QFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRL 261
            ...:|..:..... |....:...|.:.: |...:....:.:.|.::..|.:..:|...||.:
  Fly  1686 RTQSAKTIEIRTG-SQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQAK--- 1746

  Fly   262 KRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREE-- 324
                   |.|...|:|.||..:.:.     :.||.....:...|..|...:.|....|....|
  Fly  1747 -------RLSCMEEEISSLTSQSQA-----ISARASALGEGCFPNLRSPTFDSKFPLKPAPAESI 1799

  Fly   325 -----------KMRT-------------QRRSADTVDGSG-RTSTANNPSGTTASSSVATSNNST 364
                       ||.|             |:|||    .|| :.:|::....:.||||.||    |
  Fly  1800 VPGYATVPAATKMLTAPPPGFLQQQQQQQQRSA----FSGYQATTSSVQQSSFASSSKAT----T 1856

  Fly   365 PGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTM 429
            ..:.:|:.:.:...|.|..|.||.:||...|....:|.|.:.||.....:|.....|
  Fly  1857 SSLSSSSASASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRP-------- 1913

  Fly   430 YSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQ 494
                  .||::....::|..:..||....:...|  |..|:...|  |.|:..|.|..|:.|...
  Fly  1914 ------SIASITAPGSASAPAPVPSAAPTKATAP--FKAPIVPKS--VIANAVNAAAPPAPAVFP 1968

  Fly   495 PPQHGVYTNSSPMPSSNTGVISAG 518
            |....:..||:...|...|..|||
  Fly  1969 PDLSDLNLNSNVDNSPGAGGKSAG 1992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	26/145 (18%)
		COG5576	<253..368	CDD:227863	32/141 (23%)
		Homeobox	269..322	CDD:395001	12/52 (23%)
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030