Protein Alignment toy and EVX2

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001073927.1
• Gene: EVX2 / 344191
• HGNCID: 3507
• Length: 476
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 104/452 - (23%)
• Similarity: 159/452 - (35%)
• Gaps: 124/452 - (27%)

  Fly    51 RQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSK------PRVATTPVV 109
            |::::.:......|....|...:||...:.:|           .|:..|:      ||:.:.|:.
Human     6 RKEMILMERGLHSPTAGKRFSNLSNSAGNAVL-----------EALENSQHPARLSPRLPSAPLH 59

  Fly   110 QKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPS--VSSINRVLRNLASQKEQQAQQQNESVYE 172
            ..:.    |.|:...:|| |.|.:.|...|::..|  :||.....:......|..|:....|..|
Human    60 SALG----ELPAKGKFEI-DTLFNLQHTGSESTVSSEISSAAESRKKPGHYSEAAAEADMSSDVE 119

  Fly   173 ----KLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEVSH 233
                .||...|.  |.|....|....:.....||...|| |:.||                 :..
Human   120 VGCSALRSPGGL--GAAQLKENNGKGYAESGSAAGTTTS-ASGSG-----------------LGS 164

  Fly   234 TNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERL 298
            .:.....|.|::....||....|:|        |.||:|:.|||..|||||.|.:|.....|..|
Human   165 LHGGSGGSGGSAALGGSGSGADQVR--------RYRTAFTREQIARLEKEFYRENYVSRPRRCEL 221

  Fly   299 ADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSAD----TVDGSGRTSTANNP----------- 348
            |..:.|||..|:|||.|||.|.:|:....:....||    |...:...:|.:.|
Human   222 AAALNLPETTIKVWFQNRRMKDKRQRLAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHVPLHY 286

  Fly   349 ---SGTTASSSVATSNNST-----------------------------------PGI-------- 367
               .|.||:::.|.::.:.                                   ||:
Human   287 YPHVGVTAAAAAAAASGAAAAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQAPAAAA 351

  Fly   368 -VNSAINVAERTSSALVSNSLPEASNGPTVLGGEAN----TTHTSSESPPLQPAAPRLPLNS 424
             :|||.:.|...::|..:.|...|:..|. .||.|.    :.| ||:|.....||....|.|
Human   352 GLNSAASAAAAAAAAAAAASSAAAAGAPP-SGGSAPCSCLSCH-SSQSAAAAAAAAAAALGS 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	22/109 (20%)
		COG5576	<253..368	CDD:227863	42/176 (24%)
		Homeodomain	267..322	CDD:459649	28/54 (52%)
EVX2	NP_001073927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..113		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..185		11/60 (18%)
		Homeodomain	189..245	CDD:459649	29/63 (46%)