DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and HOXB8

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_076921.1	Gene:	HOXB8 / 3218	HGNCID:	5119	Length:	243	Species:	Homo sapiens

Alignment Length:	203	Identity:	50/203 - (24%)
Similarity:	82/203 - (40%)	Gaps:	46/203 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 MFNGQTGGWAWYPSN-----------TTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSV 229
            ::...:||...:||.           :|..:...|.|.:....|.|..|.   |.:|::.| |..
Human    39 VYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGY---DPLQRQSL-FGA 99

  Fly   230 E----VSHTNSHDSTSDGNSEHNSSGDEDSQ--------MRLRLKRKLQRNRTSFSNEQIDSLEK 282
            :    |.:.:...:.:.|..| .:.|.|.|.        ||.:.....:|.|.::|..|...|||
Human   100 QDPDLVQYADCKLAAASGLGE-EAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEK 163

  Fly   283 EFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRRE----------------EKMRTQR- 330
            ||....|.....|..::..:||.|.::::||.|||.||::|                ||.:.:|
Human   164 EFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKQKLERA 228

  Fly   331 -RSADTVD 337
             .:||..|
Human   229 PEAADEGD 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	32/111 (29%)
		Homeobox	269..322	CDD:395001	20/52 (38%)
HOXB8	NP_076921.1	Antp-type hexapeptide	134..139		0/4 (0%)
		Homeobox	150..203	CDD:395001	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..243		7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940