DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and HOXA3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	408	Identity:	94/408 - (23%)
Similarity:	138/408 - (33%)	Gaps:	129/408 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 PSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEV----------SHTNSHDSTSD 242
            |:.|..|    ||..|..:.|.|.|......:..|..|..|..|          |..|:...||.
Human   112 PAPTPAA----PPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSS 172

  Fly   243 GNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEA 307
            .:|..:.:||:....:...||.    ||::::.|:..|||||....|.....|..:|:.:.|.|.
Human   173 SSSGESCAGDKSPPGQASSKRA----RTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTER 233

  Fly   308 RIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAI 372
            :|::||.|||.|:::::|            |.|..:::...|
Human   234 QIKIWFQNRRMKYKKDQK------------GKGMLTSSGGQS----------------------- 263

  Fly   373 NVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQ-- 435
                           |..|..|...||..|:.|:...|.|.:|.:|         ..:|..||
Human   264 ---------------PSRSPVPPGAGGYLNSMHSLVNSVPYEPQSP---------PPFSKPPQGT 304

  Fly   436 ---PIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA---HQQ 494
               |.|    :|.:||    |||                  :|......|.||....|.   ...
Human   305 YGLPPA----SYPASL----PSC------------------APPPPPQKRYTAAGAGAGGTPDYD 343

  Fly   495 PPQHGVYTNSSPMPSSNTGVISAGVSVPVQISTQNVSDLTGSNYWPRLQXSSIFGSPLDHLSKAT 559
            |..||:..|.    |..|..|...   ||.:....|..::.|.       .::||  |.||..|.
Human   344 PHAHGLQGNG----SYGTPHIQGS---PVFVGGSYVEPMSNSG-------PALFG--LTHLPHAA 392

  Fly   560 AAAIIAAQAAE--KSHKH 575
            :.|:....|..  ..|.|
Human   393 SGAMDYGGAGPLGSGHHH 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	26/114 (23%)
		Homeobox	269..322	CDD:395001	20/52 (38%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		11/38 (29%)
		Antp-type hexapeptide	155..160		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		9/40 (23%)
		Homeobox	195..248	CDD:395001	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		31/175 (18%)
		DUF4074	378..441	CDD:404218	11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443		3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910