DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and PDLIM3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_055291.2	Gene:	PDLIM3 / 27295	HGNCID:	20767	Length:	364	Species:	Homo sapiens

Alignment Length:	197	Identity:	44/197 - (22%)
Similarity:	68/197 - (34%)	Gaps:	61/197 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 GRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTT 404
            ||:|..:.|||....     |..|||..|::.                      .|:..|:....
Human   130 GRSSGCSTPSGIDCG-----SGRSTPSSVSTV----------------------STICPGDLKVA 167

  Fly   405 HTSSESPPLQPAAPRLPL-NSGFNT---MYSSIPQPIATMAENYNSSLGSM------TPSCLQQR 459
            ...:.:.||:...|.:.: ::.|||   :||. ...:.|:....:::||..      |.|...:.
Human   168 AKLAPNIPLEMELPGVKIVHAQFNTPMQLYSD-DNIMETLQGQVSTALGETPLMSEPTASVPPES 231

  Fly   460 DAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSSNTGVISAG---VSV 521
            |.| .|.||            :||   .|:    ||.|.|.:.....|....:....||   |..
Human   232 DVY-RMLHD------------NRN---EPT----QPRQSGSFRVLQGMVDDGSDDRPAGTRSVRA 276

  Fly   522 PV 523
            ||
Human   277 PV 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	10/27 (37%)
		Homeobox	269..322	CDD:395001
PDLIM3	NP_055291.2	PDZ_signaling	2..80	CDD:238492
		DUF4749	184..263	CDD:374237	23/99 (23%)
		LIM_ALP	294..346	CDD:188834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030