DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and GBX1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001092304.1	Gene:	GBX1 / 2636	HGNCID:	4185	Length:	363	Species:	Homo sapiens

Alignment Length:	300	Identity:	62/300 - (20%)
Similarity:	102/300 - (34%)	Gaps:	77/300 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 IKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNL 155
            :.|:|:..: |..|..|.:..:|.:.....:.|...:           ...:||:.::...|.:.
Human    56 VLPQALAPA-PLPAGLPPLAPLASFAGRLTNTFCAGL-----------GQAVPSMVALTTALPSF 108

  Fly   156 ASQKE-----QQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSP------- 208
            |...:     |:......:........|.:.||..  |.....|...||....|...|
Human   109 AEPPDAFYGPQELAAAAAAAAATAARNNPEPGGRR--PEGGLEADELLPAREKVAEPPPPPPPHF 171

  Fly   209 ------ANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRL-------- 259
                  ....|:....|.:|.|         .::.|.......|..|.||.:....|
Human   172 SETFPSLPAEGKVYSSDEEKLE---------ASAGDPAGSEQEEEGSGGDSEDDGFLDSSAGGPG 227

  Fly   260 -------RLKRKL---------------------QRNRTSFSNEQIDSLEKEFERTHYPDVFARE 296
                   :||..|                     :|.||:|::||:..|||||....|..:..|.
Human   228 ALLGPKPKLKGSLGTGAEEGAPVTAGVTAPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERS 292

  Fly   297 RLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTV 336
            ::|..:.|.|.::::||.||||||:|.:......||.:.|
Human   293 QIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGEPV 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	9/61 (15%)
		COG5576	<253..368	CDD:227863	31/119 (26%)
		Homeobox	269..322	CDD:395001	23/52 (44%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..265		23/147 (16%)
		Homeobox	264..317	CDD:306543	22/52 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910