Protein Alignment toy and Pitx2

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001035967.1
• Gene: Pitx2 / 18741
• MGIID: 109340
• Length: 324
• Species: Mus musculus
• Alignment Length: 344
• Identity: 101/344 - (29%)
• Similarity: 147/344 - (42%)
• Gaps: 74/344 - (21%)

  Fly   201 AASVVTSPANLSGQADRDDVQKRELQFSVEVSHTNS-----HDSTSDGNSEHNSSGDEDSQMRLR 260
            |.:.|.:|    ||....|..|..|:... :|.|:|     .|....|.:|  ..|.||...
Mouse    34 AMASVLAP----GQPRSLDSSKHRLEVHT-ISDTSSPEVAEKDKGQQGKNE--DVGAEDPSK--- 88

  Fly   261 LKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEK 325
             |::.:|.||.|:::|:..||..|:|..|||:..||.:|....|.|||::|||.|||||||:.|:
Mouse    89 -KKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER 152

  Fly   326 MRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAER--TSSALVSNSLP 388
                         :.:.....|..|...:..:...::..||.  |..|.|.:  ||::|.:.|.|
Mouse   153 -------------NQQAELCKNGFGPQFNGLMQPYDDMYPGY--SYNNWAAKGLTSASLSTKSFP 202

  Fly   389 EASNGPTV--LGGEA-----NTTHTSSESPPLQPAA----PRLPLNSGFNTMYSSIPQPIATMAE 442
             ..|...|  |..::     |:..:.|.|..:.|:|    |...|||..|....|.|
Mouse   203 -FFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSP-------- 258

  Fly   443 NYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA--HQQPPQHGVYTNSS 505
            :.||::  .||:|       ||....|     |||   :|:| ||.|.|  ..:..||..:..:|
Mouse   259 SLNSAV--PTPAC-------PYAPPTP-----PYV---YRDT-CNSSLASLRLKAKQHSSFGYAS 305

  Fly   506 PM-PSSNTGVISAGVSVPV 523
            .. |:||.......|..||
Mouse   306 VQNPASNLSACQYAVDRPV 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	37/114 (32%)
		Homeodomain	267..322	CDD:459649	28/54 (52%)
Pitx2	NP_001035967.1	Homeodomain	93..149	CDD:459649	28/55 (51%)
		OAR	282..299	CDD:461067	6/17 (35%)