DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and Pitx1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_035227.1	Gene:	Pitx1 / 18740	MGIID:	107374	Length:	315	Species:	Mus musculus

Alignment Length:	267	Identity:	81/267 - (30%)
Similarity:	111/267 - (41%)	Gaps:	66/267 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 GDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSN 315
            |.||...    |:|.:|.||.|:::|:..||..|:|..|||:..||.:|....|.|.|::|||.|
Mouse    80 GAEDPAK----KKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKN 140

  Fly   316 RRAKWRREEKMRTQRRSADTVDG------SGRTS------TANNPSGTTASSSVATSNNSTPGIV 368
            ||||||:.|:    .:..|...|      ||...      .|.......|:.|:|.:..||....
Mouse   141 RRAKWRKRER----NQQLDLCKGGYVPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFT 201

  Fly   369 --NSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYS 431
              ||        .|.|.|.|:..|   |:.:   ::.|..||..|...|..|    |||.|
Mouse   202 FFNS--------MSPLSSQSMFSA---PSSI---SSMTMPSSMGPGAVPGMP----NSGLN---- 244

  Fly   432 SIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA--HQQ 494
                       |.|:..||...|.:.. .|.||.     :..|||  :.:|:| ||.|.|  ..:
Mouse   245 -----------NINNLTGSSLNSAMSP-GACPYG-----TPASPY--SVYRDT-CNSSLASLRLK 289

  Fly   495 PPQHGVY 501
            ..||..:
Mouse   290 SKQHSSF 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	43/126 (34%)
		Homeobox	269..322	CDD:395001	26/52 (50%)
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		10/27 (37%)
		Homeobox	94..147	CDD:365835	26/52 (50%)
		Interaction with PIT-1	151..280		41/170 (24%)
		Forkhead_N	196..>275	CDD:369872	31/119 (26%)
		OAR	277..294	CDD:367680	6/17 (35%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	281..294		3/12 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	287..291		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940