Protein Alignment toy and Pax8

DIOPT Version :9

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Alignment Length: 535
• Identity: 185/535 - (34%)
• Similarity: 247/535 - (46%)
• Gaps: 139/535 - (25%)

  Fly    13 PHSSVGQSTLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGC 77
            ||:|:         .:||.|:|||||.:|||||||:..||:||:|||.|.|||||||.|:||:||
Mouse     2 PHNSI---------RSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGC 57

  Fly    78 VSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNI 142
            ||||||||||||||:|..||||||:|||..||:||.||||:.|::||||||||||:|.||::|.:
Mouse    58 VSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTV 122

  Fly   143 PSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPA-----A 202
            ||||||||::|.    |.||.             ||        .|.::..|..:|.|.     :
Mouse   123 PSVSSINRIIRT----KVQQP-------------FN--------LPMDSCVATKSLSPGHTLIPS 162

  Fly   203 SVVTSPAN--------------LSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDE 253
            |.||.|.:              |.|.|...:..||::..|.:.|...|.||.|      :|||
Mouse   163 SAVTPPESPQSDSLGSTYSINGLLGIAQPGNDNKRKMDDSDQDSCRLSIDSQS------SSSG-- 219

  Fly   254 DSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRA 318
                    .||..|..| ||...:::||..|||.|||:.:|                   |....
Mouse   220 --------PRKHLRTDT-FSQHHLEALECPFERQHYPEAYA-------------------SPSHT 256

  Fly   319 KWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASS-----------SVATSNNSTPGIVNSAI 372
            |..:.........|| ..||....:::|.|.|...|:           |.......||.:.:|:.
Mouse   257 KGEQGLYPLPLLNSA-LDDGKATLTSSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSSS 320

  Fly   373 NVAERTSSALVS-----------------NSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRL 420
            ..:..:|||.:.                 |:.|.|::......|:|..:......|.|....|.:
Mouse   321 TPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHI 385

  Fly   421 PLNSGFNTMYSSIPQPIATM--AENYNSSLGSMTPSCLQQRDAYPYMFHDPLS--LGSPYVSAHH 481
            | .||..:..||   .||.|  ...|:.:..|.||     ..:|...:..|.|  |.|||    :
Mouse   386 P-TSGQGSYASS---AIAGMVAGSEYSGNAYSHTP-----YSSYSEAWRFPNSSLLSSPY----Y 437

  Fly   482 RNTACNPSAAHQQPP 496
            .::...|||    ||
Mouse   438 YSSTSRPSA----PP 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	90/123 (73%)
		COG5576	<253..368	CDD:227863	28/125 (22%)
		Homeobox	269..322	CDD:395001	14/52 (27%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	90/123 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		20/80 (25%)
		Pax2_C	344..455	CDD:372091	32/122 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910