Protein Alignment toy and Pax6

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_038655.1
• Gene: Pax6 / 18508
• MGIID: 97490
• Length: 436
• Species: Mus musculus
• Alignment Length: 542
• Identity: 271/542 - (50%)
• Similarity: 315/542 - (58%)
• Gaps: 138/542 - (25%)

  Fly    30 HSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQ--------------VSNGCVSK 80
            |||:||||||:||||||||||||||||||||||||||||||||              ||||||||
Mouse     5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSK 69

  Fly    81 ILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSV 145
            |||||||||||:|||||||||||||..||.|||.||||||||||||||||||||.||.:||||||
Mouse    70 ILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV 134

  Fly   146 SSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGW----AWYPSNTTTAHLTLPPAASVVT 206
            ||||||||||||:|:|...   :.:|:||||.|||||.|    .|||.
Mouse   135 SSINRVLRNLASEKQQMGA---DGMYDKLRMLNGQTGSWGTRPGWYPG----------------- 179

  Fly   207 SPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTS 271
              .::.||..:|..|::|    ....:|||..|        |....:::||||:|||||||||||
Mouse   180 --TSVPGQPTQDGCQQQE----GGGENTNSISS--------NGEDSDEAQMRLQLKRKLQRNRTS 230

  Fly   272 FSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTV 336
            |:.|||::||||||||||||||||||||.||.||||||||||||||||||||||:|.|||.|
Mouse   231 FTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQA--- 292

  Fly   337 DGSGRTSTANNPSGTTASSSVATS------NNSTPGIVNSAINVAERTSSALVSNSLPEASNGPT 395
                    :|.||....|||.:||      ..:||        |:..||.:::
Mouse   293 --------SNTPSHIPISSSFSTSVYQPIPQPTTP--------VSSFTSGSML------------ 329

  Fly   396 VLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSI-PQPIATMAENYNSSLGSMTPSCLQQR 459
               |..:|..|::                     ||:: |.|..|||.|.     .|.|....|.
Mouse   330 ---GRTDTALTNT---------------------YSALPPMPSFTMANNL-----PMQPPVPSQT 365

  Fly   460 DAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSS---NTGVISAGVSV 521
            .:|..|...     ||.|:....:|        ..||....:.||.||.:|   :||:||.||||
Mouse   366 SSYSCMLPT-----SPSVNGRSYDT--------YTPPHMQTHMNSQPMGTSGTTSTGLISPGVSV 417

  Fly   522 PVQISTQNVSDLTGSNYWPRLQ 543
            |||:..   |:...|.||||||
Mouse   418 PVQVPG---SEPDMSQYWPRLQ 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	112/136 (82%)
		COG5576	<253..368	CDD:227863	78/120 (65%)
		Homeodomain	267..322	CDD:459649	48/54 (89%)
Pax6	NP_038655.1	PAX	4..142	CDD:128645	112/136 (82%)
		Homeodomain	226..281	CDD:459649	48/54 (89%)