DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and Pax5

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_032808.1	Gene:	Pax5 / 18507	MGIID:	97489	Length:	391	Species:	Mus musculus

Alignment Length:	483	Identity:	167/483 - (34%)
Similarity:	222/483 - (45%)	Gaps:	133/483 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKP 93
            ||.|:||||||:||||||||..||:||||||.|.|||||||.|:||:||||||||||||||||||
Mouse    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKP 80

  Fly    94 RAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQ 158
            ..||||||:|||..||:|||:|||:.|::||||||||||:|:||::|.:||||||||::|....|
Mouse    81 GVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQ 145

  Fly   159 -KEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASV--------VTSPANLSGQ 214
             ..|.....:.|:.        .||      |.|..:.::...|.|.        :|||:
Mouse   146 PPNQPVPASSHSIV--------STG------SVTQVSSVSTDSAGSSYSISGILGITSPS----- 191

  Fly   215 ADRDDVQKRELQFSVEVSHT-NSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQID 278
               .|..||:....::.|.. |.|.............||                  .|:.:|::
Mouse   192 ---ADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGD------------------LFTQQQLE 235

  Fly   279 SLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTS 343
            .|::.|||.||.|:|.                                               |:
Mouse   236 VLDRVFERQHYSDIFT-----------------------------------------------TT 253

  Fly   344 TANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSS 408
            ....|..||..|::|   :...|:.:...|:...| .|.:.:|:|...:.|.|.|.:..:|....
Mouse   254 EPIKPEQTTEYSAMA---SLAGGLDDMKANLTSPT-PADIGSSVPGPQSYPIVTGRDLASTTLPG 314

  Fly   409 ESPPLQPA------APRL----PLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYP 463
            ..|.:.||      ||.|    | .|.|:....|.||     ..:||.|
Mouse   315 YPPHVPPAGQGSYSAPTLTGMVP-GSEFSGSPYSHPQ-----YSSYNDS---------------- 357

  Fly   464 YMFHDPLSLGSPYVSAHHRNTACNPSAA 491
            :.|.:|..|||||..:.....|..|:||
Mouse   358 WRFPNPGLLGSPYYYSPAARGAAPPAAA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	94/123 (76%)
		COG5576	<253..368	CDD:227863	17/114 (15%)
		Homeobox	269..322	CDD:395001	10/52 (19%)
Pax5	NP_032808.1	PAX	16..140	CDD:128645	94/123 (76%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		32/47 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		9/43 (21%)
		Pax2_C	285..389	CDD:289189	34/124 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910