DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and Pax4

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_035168.1	Gene:	Pax4 / 18506	MGIID:	97488	Length:	349	Species:	Mus musculus

Alignment Length:	362	Identity:	150/362 - (41%)
Similarity:	193/362 - (53%)	Gaps:	99/362 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKP 93
            |.|.:|||||::|||||||..|||:||:||..|.|||||||.|:||||||||||||||.||.::|
Mouse     5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEP 69

  Fly    94 RAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQ 158
            :.|||||||:||..||.:||..|.|.|::|||||:.:|.:|.:|..|..|||||||||||
Mouse    70 KCIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLR----- 129

  Fly   159 KEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPA--ASVVTSPANLSGQADRDDVQ 221
                |.|:::|::            |....|          ||  |.|:.||.:..| |.|
Mouse   130 ----ALQEDQSLH------------WTQLRS----------PAVLAPVLPSPHSNCG-APR---- 163

  Fly   222 KRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFER 286
                         ..|..||                        .||||.||..|.::|||||:|
Mouse   164 -------------GPHPGTS------------------------HRNRTIFSPGQAEALEKEFQR 191

  Fly   287 THYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGT 351
            ..|||..||.:||....|||..::||||||||||||:||::.:               |..|.
Mouse   192 GQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWE---------------AQLPG-- 239

  Fly   352 TASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLP 388
             ||..:....|| |||::     |:::..::.|.:||
Mouse   240 -ASQDLTVPKNS-PGIIS-----AQQSPGSVPSAALP 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	81/123 (66%)
		COG5576	<253..368	CDD:227863	45/114 (39%)
		Homeobox	269..322	CDD:395001	31/52 (60%)
Pax4	NP_035168.1	PAX	5..129	CDD:128645	81/123 (66%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	8..64		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	83..131		27/56 (48%)
		Homeobox	174..226	CDD:278475	30/51 (59%)
		Transcription repression	278..349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152885at2759
OrthoFinder	1	1.000	-	-		FOG0002521
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920