Protein Alignment toy and Pax2

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001355672.1
• Gene: Pax2 / 18504
• MGIID: 97486
• Length: 432
• Species: Mus musculus
• Alignment Length: 515
• Identity: 176/515 - (34%)
• Similarity: 231/515 - (44%)
• Gaps: 151/515 - (29%)

  Fly    23 FGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYE 87
            |.....||.|:||||||:||||||||..||:||||||.|.|||||||.|:||:||||||||||||
Mouse    10 FSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYE 74

  Fly    88 TGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVL 152
            ||||||..||||||:|||..||.|||:|||:.|::||||||||||:|.:|::|.:||||||||::
Mouse    75 TGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRII 139

  Fly   153 RNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPA---NLSG- 213
            |.    |.||.......        ...||..|  |.:|.......||.:|....|.   :::|
Mouse   140 RT----KVQQPFHPTPD--------GAGTGVTA--PGHTIVPSTASPPVSSASNDPVGSYSINGI 190

  Fly   214 -QADRDDVQKRELQFSVEVSHTNSHDSTSDG--------NSEHNSSGDEDSQMRLRLKRKLQRNR 269
             ...|.:.:||:.: .|||....:|.....|        :....|..:.|||..:...||..|..
Mouse   191 LGIPRSNGEKRKRE-EVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRAD 254

  Fly   270 TSFSNEQIDSLEKEFERTHYPDVF-ARERLADKIG----LPEARIQVWFSNRRAKWRREEKMRTQ 329
            | |:.:|:::|::.|||..||||| |.|.:..:.|    ||..
Mouse   255 T-FTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPAL---------------------- 296

  Fly   330 RRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNG- 393
                                              |||:        :...|:|.:::.||..:.
Mouse   297 ----------------------------------TPGL--------DEVKSSLSASANPELGSNV 319

  Fly   394 ------PTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMT 452
                  |.|.|.:.    ||:..|...|..|  |...|      |.|          .|:|..|.
Mouse   320 SGTQTYPVVTGRDM----TSTTLPGYPPHVP--PTGQG------SYP----------TSTLAGMV 362

  Fly   453 PSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQP----PQHGVYTNSSPMP 508
            |.             ...| |:||  :|.:.||.|.:.....|    |..|    :.|:|
Mouse   363 PG-------------SEFS-GNPY--SHPQYTAYNEAWRFSNPALLMPPPG----APPLP 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	93/123 (76%)
		COG5576	<253..368	CDD:227863	26/119 (22%)
		Homeodomain	267..322	CDD:459649	18/59 (31%)
Pax2	NP_001355672.1	PAX	16..140	CDD:128645	93/123 (76%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		31/51 (61%)
		Pax2_C	305..>390	CDD:463563	28/122 (23%)