DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and vab-3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001024570.1	Gene:	vab-3 / 181251	WormBaseID:	WBGene00006870	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	235/541 - (43%)
Similarity:	306/541 - (56%)	Gaps:	117/541 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 STAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGS 90
            |.|||:|:||||||:||||||||:|||:||:|||.|.|||||||:||||||||||||.||||:|:
Worm     2 SDAGHTGVNQLGGVFVNGRPLPDATRQRIVDLAHKGCRPCDISRLLQVSNGCVSKILCRYYESGT 66

  Fly    91 IKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNL 155
            |:|||||||||||||:.||:||.||||:.||||||||||:||::.:||::.||||||||||||||
Worm    67 IRPRAIGGSKPRVATSDVVEKIEDYKRDQPSIFAWEIRDKLLADNICNNETIPSVSSINRVLRNL 131

  Fly   156 ASQKEQQAQQQNESVYEKLRMFNGQTGGWAWY-----PSNTTTAHLTLPPAASVVTSPANLSGQA 215
            |::|||...|  ..:|:::|:.:......:||     |.|.........||..:   .....|:.
Worm   132 AAKKEQVTMQ--TELYDRIRIVDNFPYNSSWYGQWPIPMNGAVGLNPFVPAPLI---EPKTEGEF 191

  Fly   216 DRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSL 280
            ::|:.||..                        :..::|:..|:|||||||||||||:..||:||
Worm   192 EKDEDQKPP------------------------TEPEDDAAARMRLKRKLQRNRTSFTQVQIESL 232

  Fly   281 EKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTA 345
            |||||||||||||||||||.||.|||||||||||||||||||||||| .:||:.|:|     |:.
Worm   233 EKEFERTHYPDVFARERLAQKIQLPEARIQVWFSNRRAKWRREEKMR-NKRSSGTMD-----SSL 291

  Fly   346 NNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSES 410
            :|.:.|....||..||.:.|      |.....|.:...||:   ::|.||     .|....:|:
Worm   292 SNGTPTPTPGSVTGSNMTNP------IGSPASTPNRFPSNN---SANLPT-----TNFVPQTSQ- 341

  Fly   411 PPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLG---SMTPSCLQQRDAYP----YMFHD 468
                              ||:.:.||   ..:.|:..:.   ||.|        ||    :..|.
Worm   342 ------------------MYAGLSQP---AMDPYSFGIANGFSMAP--------YPQVTDFQPHH 377

  Fly   469 PLSLGSPYVSAHHRNTACNPSAAHQQPPQ-HGVYTNSSPMPSS--NTGVISAGVSVPVQISTQNV 530
            .....|||...:.|           .|.. ||...:.||..::  :...:|:|:|:||.....::
Worm   378 MFQGRSPYDFPYPR-----------MPTNGHGFQQSMSPATTAVGDIPTLSSGMSLPVSAVLNSI 431

  Fly   531 ------------SDLTGSNYW 539
                        ||||..:||
Worm   432 DPSLTHSQMHELSDLTQEHYW 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	96/123 (78%)
		COG5576	<253..368	CDD:227863	76/114 (67%)
		Homeobox	269..322	CDD:395001	46/52 (88%)
vab-3	NP_001024570.1	PAX	5..129	CDD:128645	96/123 (78%)
		COG5576	183..293	CDD:227863	73/142 (51%)
		Homeobox	221..274	CDD:395001	46/52 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I1598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1212
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2514
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152885at2759
OrthoFinder	1	1.000	-	-		FOG0002521
OrthoInspector	1	1.000	-	-		oto18518
orthoMCL	1	0.900	-	-		OOG6_105713
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	1	1.000	-	-		X2218
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800