DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and alp-1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001023371.1	Gene:	alp-1 / 177701	WormBaseID:	WBGene00001132	Length:	1424	Species:	Caenorhabditis elegans

Alignment Length:	671	Identity:	136/671 - (20%)
Similarity:	237/671 - (35%)	Gaps:	192/671 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CSTAGHSGINQLGGVYV---------------NGRP-------------------LPDSTRQKIV 55
            |:|.|:| :..:|..::               .|||                   :.||.|....
Worm   246 CATCGNS-LRNVGHHFIEDKFYCDIHGTQRKHGGRPGMDPNIFVKSSPTAAQPVHIQDSPRAAYH 309

  Fly    56 ELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRE-- 118
            ...:: |||..:|    .:....||.:..:|.|    |:..|...|.....|.....||..:.
Worm   310 PQVNT-ARPVSVS----PAPSAGSKTVTTHYHT----PKTQGILSPGQRGVPTAAFGADLSKSVT 365

  Fly   119 -------------------CPSIFAWEIRDRLLSEQVCNSDNI---PSVSSINRVLRNLASQKEQ 161
                               .||.::.:.|::  |:|......:   |.|.|      |.....||
Worm   366 YGGGVGPGGTHYDSNRLSPAPSQYSTQSRNQ--SQQHYQQHVVQAPPPVPS------NPPPSNEQ 422

  Fly   162 QAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQ 226
            |:|.:.:::.:.:|.        |..|..:..:....||.|...|   |...|.|..|..|:|
Worm   423 QSQSRVQNLPDSVRS--------AVSPRRSGKSPRQWPPPAMPTT---NRYWQIDPADALKKE-- 474

  Fly   227 FSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQ--RNRTSFSNEQI-DSLEKEFERTH 288
                  ..|..:.......|...|.:::.:::...|:..:  |..::.|.||: .:.|::.:||.
Worm   475 ------KVNYGEDLVALIKEVEQSKEKEPKVKKEPKKGTRGARRASNISKEQVQQAFEEQRKRTE 533

  Fly   289 YPDVFARERLADKI-GLPEARIQVWFSNRRAKWRR--EEKMRTQRRSADTVDGSGRT------ST 344
            ..::   ::|..:| ..||.:::|..........:  ||............||...|      ..
Worm   534 RKEI---KKLEKEIKPKPELKVEVPVEPLVVPTSKPLEEPCPEALPPPKINDGIHWTVIHSPVLR 595

  Fly   345 ANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSS- 408
            :.:|:..|:.:::..||    |:|....:.|.: ...:...|.|:    |...|.:....|.||
Worm   596 SPSPAKVTSEAAIPESN----GVVKPIPSYASQ-PIGISKTSTPQ----PFRPGSQVERPHYSSV 651

  Fly   409 -----ESP-PLQPAAPRLPLNSGFNTMYSSIPQPIATMAENY--NSSLGSMTPSC-LQQRDAYPY 464
                 .:| ||    ||.|.:|         |||:    ::|  .||..::|.|. ||......|
Worm   652 GLKDVHAPVPL----PRSPQHS---------PQPV----QSYIVRSSDANVTTSTNLQTTVTRQY 699

  Fly   465 MFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSSNTG-VISAGVSVPVQISTQ 528
            ..:|                  |.|...|||....:.:::||:|:.... ......|.|:.:.|.
Worm   700 TEND------------------NKSQFLQQPHPDTIDSSTSPIPTIRLNRHTKPEPSTPLSVPTV 746

  Fly   529 NVSDLT--------GSNYWPRLQXSSIFGSPLD-HLSKATAAAIIAAQAAEKS---HKHRK---- 577
            :::|:.        .|..| |.. |:...||:. |.|:        .|..::|   |:|.:
Worm   747 SINDIATSPIKITEPSRPW-RASVSNSATSPIKIHESR--------VQPVDESRGLHRHEEKAQI 802

  Fly   578 EHSIVSIHTTKRKKNPPSLKR 598
            |.|.:.||  :....|||:.:
Worm   803 ETSTIKIH--EPSSPPPSVHK 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	31/181 (17%)
		COG5576	<253..368	CDD:227863	23/126 (18%)
		Homeobox	269..322	CDD:395001	11/54 (20%)
alp-1	NP_001023371.1	PDZ_signaling	5..80	CDD:238492
		DUF4749	137..>197	CDD:292558
		ZM	137..162	CDD:128974
		LIM_ALP_like	220..271	CDD:188746	5/25 (20%)
		LIM1_Enigma_like_1	1251..1304	CDD:188839
		LIM	1312..1363	CDD:295319
		LIM3_Enigma_like_1	1371..1424	CDD:188845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030