DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and Lhx5

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_620605.1	Gene:	Lhx5 / 124451	RGDID:	71079	Length:	402	Species:	Rattus norvegicus

Alignment Length:	329	Identity:	79/329 - (24%)
Similarity:	114/329 - (34%)	Gaps:	109/329 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 RDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLE 281
            :||.::.:       :.|:|...|::..:|..:||           .|.:..||:...:|:::|:
  Rat   150 QDDPKETD-------NSTSSDKETANNENEEQNSG-----------TKRRGPRTTIKAKQLETLK 196

  Fly   282 KEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKM-----------RTQRRSADT 335
            ..|..|..|....||:||.:.||....|||||.|||:|.||.:::           |:.||....
  Rat   197 AAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPL 261

  Fly   336 VDGSGRT-------STANNPSGTTASSSVATSNN---STPGIVNSAINVAERTSSALVSNSLPEA 390
               .||.       ||.....|...|...|...|   ...|..:.|.:.|:  ||.|       |
  Rat   262 ---GGRLDESEMLGSTPYTYYGDYQSDYYAPGGNYDFFAHGPPSQAQSPAD--SSFL-------A 314

  Fly   391 SNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSC 455
            ::||       .:|...:..|||  |.|....|..|..|.|....|             |..|..
  Rat   315 ASGP-------GSTPLGALEPPL--AGPHGADNPRFTDMISHPDTP-------------SPEPGL 357

  Fly   456 LQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTN--SSPMPSSNTGVISAG 518
                                            |.|.|..|.:  |::.  |.|.|.|.|...|..
  Rat   358 --------------------------------PGALHPMPGE--VFSGGPSPPFPMSGTSGYSGP 388

  Fly   519 VSVP 522
            :|.|
  Rat   389 LSHP 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	37/135 (27%)
		Homeobox	269..322	CDD:395001	22/52 (42%)
Lhx5	NP_620605.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753
		LIM2_Lhx1_Lhx5	64..119	CDD:188761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..186		10/53 (19%)
		Homeobox	183..237	CDD:395001	22/53 (42%)
		PHA03378	<247..>392	CDD:223065	45/212 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..402		35/160 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910