DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and Pitx1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_446076.1	Gene:	Pitx1 / 113983	RGDID:	69253	Length:	315	Species:	Rattus norvegicus

Alignment Length:	326	Identity:	93/326 - (28%)
Similarity:	131/326 - (40%)	Gaps:	80/326 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 HL--TLPPAASVVTSPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQM 257
            ||  |..|...:..| |:.|..||..|   :|.....:|.......|...|::|..:.
  Rat    32 HLARTADPREPLENS-ASESSDADLPD---KERGGEAKVPEDGGAGSAGCGSAEDPAK------- 85

  Fly   258 RLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRR 322
                |:|.:|.||.|:::|:..||..|:|..|||:..||.:|....|.|.|::|||.|||||||:
  Rat    86 ----KKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRK 146

  Fly   323 EEKMRTQRRSADTVDG------SGRT-------STANNPSGTTASSSVATSNNSTPGIV--NSAI 372
            .|:    .:..|...|      ||..       :.|.......|:.|:|.:..||....  ||
  Rat   147 RER----NQQLDLCKGGYVPQFSGLVQPYEDVYAAAGYSYNNWAAKSLAPAPLSTKSFTFFNS-- 205

  Fly   373 NVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPI 437
                  .|.|.|.|:..|   |:.:   ::.|..||..|...|..|    |||.|
  Rat   206 ------MSPLSSQSMFSA---PSSI---SSMTMPSSMGPGSVPGMP----NSGLN---------- 244

  Fly   438 ATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA--HQQPPQHGV 500
                 |.|:..||...|.:.. .|.||.     :..|||  :.:|:| ||.|.|  ..:..||..
  Rat   245 -----NINNLTGSSLNSAMSP-GACPYG-----TPASPY--SVYRDT-CNSSLASLRLKSKQHSS 295

  Fly   501 Y 501
            :
  Rat   296 F 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	41/127 (32%)
		Homeobox	269..322	CDD:395001	26/52 (50%)
Pitx1	NP_446076.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		22/85 (26%)
		Homeobox	93..146	CDD:395001	26/52 (50%)
		Interaction with PIT-1. /evidence=ECO:0000250	149..280		41/176 (23%)
		OAR	277..294	CDD:397759	6/17 (35%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	281..294		3/12 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	287..291		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910