DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and pitx3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_002935807.2	Gene:	pitx3 / 100496690	XenbaseID:	XB-GENE-486162	Length:	292	Species:	Xenopus tropicalis

Alignment Length:	342	Identity:	96/342 - (28%)
Similarity:	137/342 - (40%)	Gaps:	94/342 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 DVQKRELQFSVEVSHTNSHDSTSDG-------NSEHNSSGD---EDSQMRLRLKRKLQRNRTSFS 273
            |.:.|....|:..|.|..||.:..|       .|:.|.:.|   ||.    .||:|.:|.||.|:
Frog     8 DSEARSPALSLSDSGTPQHDHSCKGQEHSDTEKSQQNQTDDSNPEDG----TLKKKQRRQRTHFT 68

  Fly   274 NEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDG 338
            ::|:..||..|:|..|||:..||.:|....|.|||::|||.|||||||:.|:
Frog    69 SQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER------------- 120

  Fly   339 SGRTSTANNPSGTTAS----------SSVATSNNSTPGIVNS-----------AINVAERTSSAL 382
            :.:.....|..|...:          |..:.:|.:|.|:..|           ::||:..:|..:
Frog   121 NQQAELCKNSFGAQFNGLMQPYDDMYSGYSYNNWATKGLATSPLSAKSFPFFNSMNVSPLSSQPM 185

  Fly   383 VS--NSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYN 445
            .|  ||:             |:.|..||..|......|...||:..|             ..|.|
Frog   186 FSPPNSI-------------ASMTMPSSMVPSAVTGVPGSSLNNLGN-------------INNLN 224

  Fly   446 S-SLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA--HQQPPQHGVYTNSS-P 506
            | ||.|...:     .|.||     .|..|||:   :|:| ||.|.|  ..:..||..:|..: .
Frog   225 SPSLNSAVSA-----SACPY-----ASTASPYM---YRDT-CNSSLASLRLKAKQHANFTYPAVQ 275

  Fly   507 MPSSNTGVISAGVSVPV 523
            .|:||.......|..||
Frog   276 TPASNLSPCQYAVDRPV 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	41/124 (33%)
		Homeobox	269..322	CDD:395001	27/52 (52%)
pitx3	XP_002935807.2	Homeobox	64..117	CDD:395001	27/52 (52%)
pitx3	XP_002935807.2	OAR	250..267	CDD:397759	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910