Protein Alignment toy and arx

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_002933659.1
• Gene: arx / 100486727
• XenbaseID: XB-GENE-483940
• Length: 536
• Species: Xenopus tropicalis
• Alignment Length: 570
• Identity: 141/570 - (24%)
• Similarity: 220/570 - (38%)
• Gaps: 180/570 - (31%)

  Fly    42 NGRPLPDSTRQKIVELAHSGARPCD-----ISRILQVSNGCVSKILGRYYETGSI-------KPR 94
            :|.|..:.| .:|:.|..:|....|     ||:..|||   :|:  .:.|...|.       .|.
 Frog   104 SGVPRSEKT-DRILLLGGAGENTWDNHSLKISQAPQVS---ISR--SKSYRENSAPLLREEHSPE 162

  Fly    95 A-IGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRL--LSEQVCNSDNIPSVSSINRVLRNLA 156
            . :..|:.::.|:...        .|.|     ::|||  ||:...:.|:              .
 Frog   163 GLLQQSQQQIQTSATT--------ACTS-----LQDRLGALSQSPRDEDD--------------D 200

  Fly   157 SQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHL----------------TLPPAASVV 205
            .::::..:::.|...|..:..|....      ||...|||                ..||...
 Frog   201 DEEDEDEEEEEEEEDEANKQHNPNNS------SNPNRAHLQEQQHPQFQSQQSQQQQPPPGCG-- 257

  Fly   206 TSPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNS---SGDEDSQMRLRLKRKLQR 267
             :.|.||        .|.||..         |.|.:||....:|   |...||:..: ||||.:|
 Frog   258 -TDAELS--------PKEELML---------HSSDADGKDGEDSVCLSAGSDSEEGM-LKRKQRR 303

  Fly   268 NRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRS 332
            .||:|::.|::.||:.|::|||||||.||.||.::.|.|||:||||.|||||||:.||...|..
 Frog   304 YRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTH- 367

  Fly   333 ADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVL 397
            |..:...|..| |::|.|....:|....:       :.|::.|...::|..:.:.|.....|
 Frog   368 APGLPFPGPLS-ASHPLGPYLDASPFPPH-------HPALDSAWTAAAAAAAAAFPSLPPPP--- 421

  Fly   398 GGEANTTHTSSESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMT---PSCLQQR 459
                   |.|:..||                  |..|..::|.       ||:..   |:.:.
 Frog   422 -------HGSAALPP------------------SGSPLGLSTF-------LGAAVFRHPAFIS-- 452

  Fly   460 DAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSSNTGVISAGVSVPVQ 524
            .|:..:|    |..:|..||   :||   :|..:|           |.|:..:.|.|:|:|.||.
 Frog   453 PAFGRLF----STMAPLTSA---STA---AALLRQ-----------PSPAVESSVQSSGLSDPVT 496

  Fly   525 ISTQNVSDLTGSNYWPRLQXSSIFGSPL---DHLSKATAAAIIAAQAAEK 571
            .:...             : |||....|   :|.::.|...||...:|.|
 Frog   497 AAADR-------------RASSIAALRLKAKEHAAQLTQLNIIPGNSAGK 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	26/125 (21%)
		COG5576	<253..368	CDD:227863	50/114 (44%)
		Homeodomain	267..322	CDD:459649	33/54 (61%)
arx	XP_002933659.1	Homeodomain	302..358	CDD:459649	33/55 (60%)
		OAR	500..518	CDD:461067	5/30 (17%)