DRSC/TRiP Functional Genomics Resources

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Protein Alignment toy and DUX4

DIOPT Version :10

Sequence 1:NP_001368990.1 Gene:toy / 43833 FlyBaseID:FBgn0019650 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens


Alignment Length:298 Identity:77/298 - (25%)
Similarity:112/298 - (37%) Gaps:74/298 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 QRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQR 330
            :|.||:.:..|...|.:.||:..:|.:.|||.||.:.||||:|||:||.||||        |...
Human    95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRA--------RHPG 151

  Fly   331 RSADTVDGSGRTSTANNPSGTTASSSVATSNNS-------------TPGIV--NSAINVAERTSS 380
            :.......:|...:|....|..|.|.||.::..             .||.:  .:.::.|.|.:.
Human   152 QGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAP 216

  Fly   381 AL-VSNSLP-EASNGPTVLGGEANTTHTSSESPP----LQPAAPRLPLNSG-----FNTMYSSIP 434
            || .|.:.| |..:.|....|:   ...::.:||    ..|.|||.|.:.|     .:.....:|
Human   217 ALQPSQAAPAEGISQPAPARGD---FAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 278

  Fly   435 QPIATM----AENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPY----VSAHHRNTACNPSAA 491
            .|.|..    |:......|.:.|               |.|.|||:    ........|..|.|.
Human   279 GPCAVAQPGPAQAGPQGQGVLAP---------------PTSQGSPWWGWGRGPQVAGAAWEPQAG 328

  Fly   492 HQQPPQHGVYTNSSPMP-----SSNTGVISAGVSVPVQ 524
            ...|||        |.|     |:..|.:. |:..|.|
Human   329 AAPPPQ--------PAPPDASASARQGQMQ-GIPAPSQ 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
toyNP_001368990.1 PAX 29..153 CDD:128645
COG5576 <253..368 CDD:227863 36/114 (32%)
Homeodomain 267..322 CDD:459649 26/54 (48%)
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
homeodomain 25..78 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102 3/6 (50%)
Homeodomain 95..149 CDD:459649 26/61 (43%)
PRK07764 <141..319 CDD:236090 44/203 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 38/167 (23%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 11/40 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424
Blue background indicates that the domain is not in the aligned region.

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