Protein Alignment toy and pax3b

DIOPT Version :10

• Sequence 1: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001315326.1
• Gene: pax3b / 100150137
• ZFINID: ZDB-GENE-080917-53
• Length: 469
• Species: Danio rerio
• Alignment Length: 537
• Identity: 167/537 - (31%)
• Similarity: 253/537 - (47%)
• Gaps: 153/537 - (28%)

  Fly    29 GHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKP 93
            |...:||||||::||||||:..|.||||:||.|.|||.|||.|:||:|||||||.||.|||||:|
Zfish    34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRP 98

  Fly    94 RAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQ 158
            .||||:|.:..:..|.:::.:||||.|.||:|||||:||.|.:|:.:|:|:||||:|::|..:..
Zfish    99 GAIGGTKSKTTSPDVEKRVEEYKRENPGIFSWEIRDKLLKEGICDRNNVPTVSSISRIMRGRSGT 163

  Fly   159 KEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKR 223
            :..:.:::.                                                |.:|:::|
Zfish   164 RADEEEEEE------------------------------------------------DEEDIERR 180

  Fly   224 ELQFSVEVSHTNSHD---STSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFE 285
            |.:   |.:|..:|.   ..:|.:|..:...:.:|:..|.||||.:|:||:|:.:|::.||:.||
Zfish   181 ERE---ENAHRGAHSIEGILADRSSPSDEGSEVESEPDLPLKRKQRRSRTTFTADQLEELERAFE 242

  Fly   286 RTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSG 350
            ||||||::.||.||.:..|.|||:|||||||||:||::
Zfish   243 RTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQ--------------------------- 280

  Fly   351 TTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQP 415
             ..::.:...|:..||      ..:....|:|....|.|:                     |..|
Zfish   281 -AGANQLMAFNHLIPG------GFSHHAMSSLSPYQLSES---------------------PYPP 317

  Fly   416 AAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPS-----CLQQRDAYPYMFHDPLSLGSP 475
            ||  ||.:||  |::.  |||   :..:.:.|.|...|.     ||..|..|           :.
Zfish   318 AA--LPQDSG--TVHR--PQP---LPHSSHQSSGGAGPEGGASYCLSSRHGY-----------TG 362

  Fly   476 YVSAH-----HRNTACN------------PS-AAHQQPPQHGVYTNSSPMPSSNTGVISAGVSVP 522
            |..|.     |.|.|.|            || |:|....:..:.:.||...|.:..:.|.. |:|
Zfish   363 YSDAFGPHNTHNNNAINNGLSSQVMGLITPSGASHPTQAEFSLDSGSSVSSSCSQRMESLS-SLP 426

  Fly   523 VQISTQNVSDLTGSNYW 539
            ...:..|....:.::::
Zfish   427 ALSNLSNPQSYSSASFY 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	74/123 (60%)
		COG5576	<253..368	CDD:227863	43/114 (38%)
		Homeodomain	267..322	CDD:459649	33/54 (61%)
pax3b	NP_001315326.1	PAX	34..158	CDD:366005	74/123 (60%)
		Homeodomain	223..279	CDD:459649	33/55 (60%)
		Pax7	346..385	CDD:403540	11/49 (22%)