DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and hoxd3

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_002935734.1	Gene:	hoxd3 / 100038058	XenbaseID:	XB-GENE-478462	Length:	415	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	107/528 - (20%)
Similarity:	168/528 - (31%)	Gaps:	220/528 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 QQAQQQNESVYEKLRMFNGQT----GGWAWYPSN------------TTTAHLTLPPAASVVTSPA 209
            ::|:.|..:.||...:|.|.|    ..:::.||.            .:||....|.|.......|
Frog    13 REAKMQKTAYYENSGLFGGYTYAKPESYSYGPSQQQYPQSSLDSDYPSTACSIQPAAIRAPNHKA 77

  Fly   210 N-LSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEH------------------------NS 249
            | :||...|            ..|..||:.:.|..|.:|                        ||
Frog    78 NDISGSCMR------------TTSSQNSNQAPSISNQQHQAPSLPPSSPSHGNSSAQKKSKSSNS 130

  Fly   250 SGDEDS-----------QMRLRLKRK-----------------------LQRNRTSFSNEQIDSL 280
            ||...:           :.|...|:|                       .:|.||::::.|:..|
Frog   131 SGSSQATLSKQIFPWMKESRQNAKQKNTSSSSSTPPGENCEEKSPTGPSSKRVRTAYTSAQLVEL 195

  Fly   281 EKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTA 345
            ||||....|.....|..:|:.:.|.|.:|::||.|||.|:::::|.:               ...
Frog   196 EKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAK---------------GIM 245

  Fly   346 NNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSES 410
            ::|:|.:...|...|.                      ||.:..:|..|||     |:....:.|
Frog   246 HSPAGQSPDRSPTLSG----------------------SNHVGYSSQLPTV-----NSLSYDAPS 283

  Fly   411 PPLQPAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSP 475
            |                |.::...|.:..:|. |.:.|.    |||.|:..||         |:.
Frog   284 P----------------TSFAKSQQNMYGLAA-YTAPLS----SCLPQQKRYP---------GAE 318

  Fly   476 YVSAHH----RNTACNPSAAHQQPPQH--GVYTNSSPM--PSSNTGVISAGVSVPVQISTQNVSD 532
            |  .||    .:...||:.  |..|.:  |.:.:|.|.  |..|.|
Frog   319 Y--EHHTMQGNSGFANPNL--QGSPVYVGGNFVDSMPASGPMFNVG------------------- 360

  Fly   533 LTGSNYWPRLQXSSIFGSPLDHLSKATAAAI---IAAQAAEKSH-----KHRKEHSIVSIHTTK- 588
                                 |||..::|::   .|||.....|     .|.....:.|.|||:
Frog   361 ---------------------HLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSSHHTTQG 404

  Fly   589 RKKNPPSL 596
            |.:..|.|
Frog   405 RMQEAPKL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	29/148 (20%)
		Homeobox	269..322	CDD:395001	20/52 (38%)
hoxd3	XP_002935734.1	Homeobox	184..237	CDD:365835	20/52 (38%)
hoxd3	XP_002935734.1	DUF4074	352..413	CDD:372548	19/101 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910