Protein Alignment PlexA and PKHD1L1

DIOPT Version :9

• Sequence 1: NP_524637.2
• Gene: PlexA / 43832
• FlyBaseID: FBgn0025741
• Length: 1945
• Species: Drosophila melanogaster
• Sequence 2: XP_016869458.1
• Gene: PKHD1L1 / 93035
• HGNCID: 20313
• Length: 4253
• Species: Homo sapiens
• Alignment Length: 1638
• Identity: 301/1638 - (18%)
• Similarity: 503/1638 - (30%)
• Gaps: 570/1638 - (34%)

  Fly    28 QTLAANIWSD---------------------KTTAQNEPINLTNAN-------APIKNAKNLNST 64
            |:..::||.|                     |....||..|:...:       .|.|....::.:
Human  1154 QSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTEGTVDIS 1218

  Fly    65 IT----NVAAFDT-KLNHLLVDTITG-----RVFVGGVN---RLYQLSPDLELSETVKTGPQNDS 116
            :|    ...|.|. ..|.|....||.     |..:|.||   :.|....:|..:..|..|.:.
Human  1219 VTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGKT-- 1281

  Fly   117 VECSILDCPLNAVR-----------------------SPTDNYN-KVLLIDRATSRLIACGSLFQ 157
              |.||......:|                       |..|..| .:..:...||.....||||.
Human  1282 --CQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFASTRDKLNSSIQYVLEVTSMFPQRGSLFG 1344

  Fly   158 GT-CTVRNL-------QNVSIIEHEVPDAVVANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNN 214
            || .|:|..       :| :::...:|..|.::..|  .:..|.     |...|:..:    |||
Human  1345 GTEITIRGFGFSTIPAEN-TVLLGSIPCNVTSSSEN--VIKCIL-----HSTGNIFRI----TNN 1397

  Fly   215 SPYRSEI--------PAVASRSLEKT----------------KMFQIAS--SAVTTGTRTFINSY 253
            .  :..:        |.|.:.|:..|                ::|.::|  |.:..| :.|.:..
Human  1398 G--KDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGYRIFSVSSPGSVIYDG-KGFTSGR 1459

  Fly   254 ARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECISDA 318
            .:.| ..::.|.|:|....|:.:..:..:|    ..::..::.:...::.:     ||:......
Human  1460 QKST-SGSFSYQFTSPGIHYYSSGYVDEAH----SIFLQGVINVLPAETRH-----IPLHLFVGR 1514

  Fly   319 QGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTPTNNSALCIYSLKSIRRKFM 383
            ...|      ..:.|..:..|..|:...:..:.|.::     .||...||           ::.:
Human  1515 SEAT------YAYGGPENLHLGSSVAGCLATEPLCSL-----NNTRVKNS-----------KRLL 1557

  Fly   384 QNIKSCFNGSGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSVPVAMFNTKLTS 448
            ..:.|||:.|    :..|:||...|...:..||..|.    |.|...:..|.|.|
Human  1558 FEVSSCFSPS----ISNITPSTGTVNELITIIGHGFS----NLPWANKVTIGSYP---------- 1604

  Fly   449 VAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKT 513
                                   .|:|.||
Human  1605 -----------------------CVVEESS----------------------------------- 1611

  Fly   514 KVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTGKCTTITS 578
                      .|..||                  ...|:::......:.:....|..|
Human  1612 ----------EDSITC------------------HIDPQNSMDVGIRETVTLTVYNLG------- 1641

  Fly   579 VVPHQLQRTTARTLELIIDH----LPQLKENLICAFTTEDKALFTNATKKRNGVNCTTPRTDMLP 639
                    |...||....|.    ||.:...|..|.:|..   .|:.|.|.:|...::....:|
Human  1642 --------TAINTLSNEFDRRFVLLPNIDLVLPNAGSTTG---MTSVTIKGSGFAVSSAGVKVL- 1694

  Fly   640 QIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAEN 704
                 ..||..|          ::|.::|..:|.|..:..:.|..:.          ..|.....
Human  1695 -----MGHFPCK----------VLSVNYTAIECETSPAAQQLVDVDL----------LIHGVPAQ 1734

  Fly   705 CRNDILVTGVSRIGPSYRSG--PGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRF- 766
            |:.:...:.:..|.| |.:|  |      |:.....:||:.|   :.:...:..|..||...:|
Human  1735 CQGNCTFSYLESITP-YITGVFP------NSVIGSVKVLIEG---EGLGTVLEDIAVFIGNQQFR 1789

  Fly   767 ---VCQFNIEGRVTSLNAQLLGDTIYCDSMEF---QYTSRSP---NLTATFAVIWGGS------- 815
               |.:.||...||.|.......::...|...   ..|..||   :|:.|...|.||:
Human  1790 AIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGN 1854

  Fly   816 -------------KPLD----NPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEE 863
                         :|..    ||:.::     ||..|.:.|:                    |:.
Human  1855 GFYPGNTTVTIGDEPCQIISINPNEVY-----CRTPAGTTGM--------------------VDV 1894

  Fly   864 QCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINC 928
            :...|.......|....:...|.:....|..||  .||.|.|.|.|.|....:|  .|.|..|.|
Human  1895 KIFVNTIAYPPLLFTYALEDTPFLRGIIPSRGP--PGTEIEITGSNFGFEILEI--SVMINNIQC 1955

  Fly   929 MPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQ--IGDY-------------RGESKEDYEFVDP 978
                       .:....||           |||  :||:             :|.:.....|..|
Human  1956 -----------NVTMANDS-----------VVQCIVGDHAGGTFPVMMHHKTKGSAMSTVVFEYP 1998

  Fly   979 -KILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGI-IE 1041
             .|.:.||..|...||..:.:||...|..:.|............|.:|.:..:|...::.|. .|
Human  1999 LNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAE 2063

  Fly  1042 GRLKMSFDNG---PREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFT-S 1101
            ...::|..||   .:....:.:...|.|.:..||         || |..|||.|::|.|:.|: :
Human  2064 QACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVS---------PKRGSTAGGTRLTVVGSGFSEN 2119

  Fly  1102 IQNPNIYVVYNGEMYASPCRVQ--SDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQN 1164
            :::.:|.:.      .:.|.|:  :.|.:.|.:     |:|.:....|:.:.        :|...
Human  2120 MEDVHITIA------EAKCDVEYSNKTHIICMT-----DAHTLSGWAPVCVH--------IRGVG 2165

  Fly  1165 LSKVHNNHFELYPN-------------PE-----------YFIFEERVKYFKSEYLTINGRNLDR 1205
            ::|:.|..| ||.:             ||           ..:.::.....|  .|.|.|..|
Human  2166 MAKLDNADF-LYVDAWSSNFSWGGKSPPEEGSLVVITKGQTILLDQSTPILK--MLLIQGGTL-- 2225

  Fly  1206 ACKESDVEVKIGNGFCNITSLSRQQL-TCRPPSEATATKSMNG----PEVIVRIGTSLEYRIGIL 1265
            ...|:|:|::..|  ..||.....|: |...|.:..|..:::|    ||:.|....:|..|.|||
Human  2226 IFDEADIELQAEN--ILITDGGVLQIGTETSPFQHKAVITLHGHLRSPELPVYGAKTLAVREGIL 2288

  Fly  1266 SYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAE 1330
            ......:.:.|..                     :|:..|:.|  |:|
Human  2289 DLHGVPVPVTWTR---------------------LAHTAKAGE--RIL----------------- 2313

  Fly  1331 CKEAFAELQTEMTDLTGD---LTSGGIPFLDYRSYAMKILFPNHEDHIVLQWERPELL---RKEK 1389
                  .||..:|...||   :.|.|                    |...|.|..::.   ....
Human  2314 ------ILQEAVTWKPGDNIVIASTG--------------------HRHSQGENEKMTIASVSAD 2352

  Fly  1390 GLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVAS---LIM----VTLQSKLEYCTDILKTL 1447
            |:.|.....:|.|.|.:.: ||.....|..|..|.:.:   ||.    |...:|:..|.|...|
Human  2353 GINITLSNPLNYTHLGITV-TLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPACPDGFDT- 2415

  Fly  1448 LGDL-IEKCIEGK 1459
             |:. .:.|::||
Human  2416 -GEFATQTCLQGK 2427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	85/510 (17%)
		PSI	522..574	CDD:279745	6/51 (12%)
		PSI	671..>699	CDD:279745	3/27 (11%)
		PSI	830..883	CDD:279745	7/52 (13%)
		IPT_plexin_repeat1	885..977	CDD:238585	25/106 (24%)
		IPT_plexin_repeat2	978..1063	CDD:238584	19/89 (21%)
		IPT	1078..1177	CDD:301692	23/102 (23%)
		IPT_PCSR	1196..>1255	CDD:238337	18/63 (29%)
		Plexin_cytopl	1353..1916	CDD:285529	25/118 (21%)
PKHD1L1	XP_016869458.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900