DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and PLXNA4

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001380826.1	Gene:	PLXNA4 / 91584	HGNCID:	9102	Length:	1894	Species:	Homo sapiens

Alignment Length:	1979	Identity:	831/1979 - (41%)
Similarity:	1150/1979 - (58%)	Gaps:	196/1979 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LTNANAPIKNAKNLNSTITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGP 112
            ||...||:...:....|.....|  ...|||:||..||.:::|.|||:|:||.||::..|.:|||
Human    26 LTRQPAPLSQKQRSFVTFRGEPA--EGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGP 88

  Fly   113 QNDSVEC----SILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-- 171
            ..|:.:|    .:..|  |...:.|:|.||:||||...:||||||||:||.|.:..|:::..:
Human    89 DEDNPKCYPPRIVQTC--NEPLTTTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGE 151

  Fly   172 -----EHEVPD--------AVVANDANSSTVAFIA---PGPPQHPVTNVMYVGVTYTNNSPYRSE 220
                 ||.:..        .|:.:.:|.....|||   .|.|::
Human   152 PYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEY--------------------- 195

  Fly   221 IPAVASRSLEKTK----MFQ-------IASS-AVTTGTRTFINSYARETYFVNYVYGFSSERFSY 273
            .|.::||.|.|..    ||.       :||. .:.:.|.|.|..:.     :.|||||||..|.|
Human   196 FPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFD-----IYYVYGFSSGNFVY 255

  Fly   274 FLTTQ--LKHSHHSSPKE--YITKLVRICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGK 334
            |||.|  :.....|:.||  |.:||||:|:||:.:.||.|:|:.|   .:.|.::.|:||.:|.|
Human   256 FLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGC---ERSGVEYRLLQAAYLSK 317

  Fly   335 PSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRG 397
            ..:.|.::||:...||:||.|||||:..  ...:.|||||:.||.|..:..:.::||:.|.|...
Human   318 AGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQSCYRGEGTLD 382

  Fly   398 LDFIS-PSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSVPV-AMFNTKLTSVAATSTSGYTVV 460
            |.::. ..:|| .:.|.||.::|||||:|:|||....:..:|| .....::|||.|.....:::.
Human   383 LAWLKVKDIPC-SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLA 446

  Fly   461 FVGTSDGFLKKVVIES-SSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCS 524
            ||||..|.|||:.::. ...|.:|.:..|.....:.|||.|...:..:|:||:.::::|.|..|.
Human   447 FVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511

  Fly   525 DYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTA 589
            .|::||:|||:.||:||||.|.|.|:.:..| :.:.:|..:.| :..:|..:| |.|:.:..:..
Human   512 QYQSCGECLGSGDPHCGWCVLHNTCTRKERC-ERSKEPRRFAS-EMKQCVRLT-VHPNNISVSQY 573

  Fly   590 RTLELIID--HLPQLKENLICAF--TTEDKALFTNATKKRNGVNCTTPRTDMLPQI--EQGKHHF 648
            ..| |:::  ::|:|...:.|.|  .:|...|...     |.:.|.:|....:|:|  |.|.||
Human   574 NVL-LVLETYNVPELSAGVNCTFEDLSEMDGLVVG-----NQIQCYSPAAKEVPRIITENGDHH- 631

  Fly   649 TAKLSVRTR-NGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVT 712
            ..:|.:::: .|....||.|.|::||.|:||..||.|.:.|.||...|.|||| .:.|
Human   632 VVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHD-PKTC------- 688

  Fly   713 GVSRIGPSYRSG----PGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNI 772
                   |::.|    |..||.:...   .::||.....|.|.:|...:.| ...|..:.|..||
Human   689 -------SFQEGRVKLPEDCPQLLRV---DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNI 743

  Fly   773 EG---RVTSLNAQLLGDTIYCDSMEFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCRE 833
            :|   ||.:|  :....::.|.:..:.|.... .||.....|:|.|...:|||....|.:|:|..
Human   744 QGSEQRVPAL--RFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCGA 806

  Fly   834 MADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRS---EICPNPEIHTFQPKTG 895
            |.:|||:||.....:.||||.....|.:.:.|...   ::.||..|   ..|.||.|....|.||
Human   807 MRESCGLCLKADPDFACGWCQGPGQCTLRQHCPAQ---ESQWLELSGAKSKCTNPRITEIIPVTG 868

  Fly   896 PWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVV 960
            |.||||.:||||.|||..:.||.|.|::||:.|.|....||..:||||.:   ||.........|
Human   869 PREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEM---GEAKPSQHAGFV 930

  Fly   961 QI------GDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPC 1019
            :|      .::...|.:.|.|:...:.|..|..||.||||::.|||.:|||||.:....... ||
Human   931 EICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQ-PC 994

  Fly  1020 KILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK- 1083
            .......|..:|.|::|..::|.::.:..|.. :...|..|:||.|||:..:.         |:
Human   995 LFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA-KIHQDLVFQYVEDPTIVRIE---------PEW 1049

  Fly  1084 GIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQSDTEMECASPVVDV--DSHVIEAER 1146
            .|.:|...|:|.||....||||.|...:.|:.:.:.|.|.:.|||.|.:|.:.:  |......||
Human  1050 SIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVLNATEMTCQAPALALGPDHQSDLTER 1114

  Fly  1147 PILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEER--VKYFKSEYLTINGRNLDRACKE 1209
            |  .|:||::||   ||:|..::..:|..||||.:..|...  ::......:.:.|:||......
Human  1115 P--EEFGFILDN---VQSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPIILKGKNLIPPVAG 1174

  Fly  1210 SDVE----VKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESS 1270
            .:|:    |.:|...|.:| :|..||.|..|:      .:...:|:.|:| .:||..|:: |.:.
Human  1175 GNVKLNYTVLVGEKPCTVT-VSDVQLLCESPN------LIGRHKVMARVG-GMEYSPGMV-YIAP 1230

  Fly  1271 NIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAF 1335
            :..|.....|..||...::|:.:  ||:|:|||:||.||...|:.:|.|||.||.|||.||||||
Human  1231 DSPLSLPAIVSIAVAGGLLIIFI--VAVLIAYKRKSRESDLTLKRLQMQMDNLESRVALECKEAF 1293

  Fly  1336 AELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQ-----WERPELLRKEKGLRIFG 1395
            |||||::.:||.||...||||||||:|.|::|||..|||.||:     ..|.|  |.||||::|.
Human  1294 AELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQE--RVEKGLKLFA 1356

  Fly  1396 QLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKS 1460
            |||.||.|||.|||||||.|.||||:|.|||||||..|||||||.||:||.||.|||:|.:|.|:
Human  1357 QLINNKVFLLSFIRTLESQRSFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKN 1421

  Fly  1461 HPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLS 1525
            |||||||||||||||||:.||||||||||||||||||:.||.|:|.|::|||:||.|.|||||||
Human  1422 HPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLS 1486

  Fly  1526 EEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNI 1590
            |:|||||.||::.:         .:.|.:.|  .:::..|.||:|:||||.|||||.|:.|::|:
Human  1487 EDKLIRQQIDYKTL---------VLSCVSPD--NANSPEVPVKILNCDTITQVKEKILDAIFKNV 1540

  Fly  1591 PSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIY 1655
            |.|.||:..|:|||||.|:..|:||.|||:|:|.|::||:||||.||.||||:.::||.||.:.|
Human  1541 PCSHRPKAADMDLEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAY 1605

  Fly  1656 NFSILSDKNEKS-HKYETLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGE 1719
            |....|..:..| .|||  |:.:|| .||...|:.:|:.....|:|::.|||||:|:...||||:
Human  1606 NAVNNSTVSRTSASKYE--NMIRYT-GSPDSLRSRTPMITPDLESGVKMWHLVKNHEHGDQKEGD 1667

  Fly  1720 RVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDP 1784
            |.:|:|||||||||||||||||||||||||||||||||||||||||||||||||:||..|||.||
Human  1668 RGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDP 1732

  Fly  1785 EVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSK 1849
            .|.||||||.||||||||:||||.|||||||::|.|:||||||||||||||||:|||||||||:|
Human  1733 HVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNK 1797

  Fly  1850 LLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNE 1914
            ||||||||.|:.||:|||.||..|..||||||||.|||:||:|..||||..||.|:::|..||:|
Human  1798 LLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSE 1862

  Fly  1915 QLTVTLEEDEFSQKQRLAFKLEQVHNIMS 1943
            ::...|:.|:...||:||:|||||..:||
Human  1863 EILGPLDHDDQCGKQKLAYKLEQVITLMS 1891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	164/487 (34%)
		PSI	522..574	CDD:279745	19/51 (37%)
		PSI	671..>699	CDD:279745	13/27 (48%)
		PSI	830..883	CDD:279745	16/55 (29%)
		IPT_plexin_repeat1	885..977	CDD:238585	38/97 (39%)
		IPT_plexin_repeat2	978..1063	CDD:238584	26/84 (31%)
		IPT	1078..1177	CDD:301692	33/101 (33%)
		IPT_PCSR	1196..>1255	CDD:238337	15/62 (24%)
		Plexin_cytopl	1353..1916	CDD:285529	368/568 (65%)
PLXNA4	NP_001380826.1	Sema_plexin_A4	39..511	CDD:200535	167/505 (33%)
		PSI	510..548	CDD:214655	17/38 (45%)
		TIG_plexin	564..654	CDD:407808	23/96 (24%)
		PSI	655..702	CDD:396154	20/61 (33%)
		TIG_2	708..802	CDD:407859	25/95 (26%)
		PSI	804..856	CDD:396154	16/54 (30%)
		IPT_plexin_repeat1	858..953	CDD:238585	38/97 (39%)
		IPT_plexin_repeat2	955..1038	CDD:238584	27/84 (32%)
		IPT_plexin_repeat3	1040..1140	CDD:238586	35/113 (31%)
		IPT_PCSR	1142..1222	CDD:238337	19/87 (22%)
		Plexin_cytopl	1311..1864	CDD:400574	368/568 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	709	1.000	Domainoid score	I119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1366	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm41887
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	LDO	PTHR22625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960