DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxna3

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001091959.1	Gene:	plxna3 / 567422	ZFINID:	ZDB-GENE-070613-1	Length:	1892	Species:	Danio rerio

Alignment Length:	1956	Identity:	810/1956 - (41%)
Similarity:	1128/1956 - (57%)	Gaps:	189/1956 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAVRS----- 131
            ||.|.||.|...||.||||.:||:|:||.:|..:.:.:|||..|:.:|    .|..:||:
Zfish    39 DTSLTHLTVHRKTGEVFVGAINRVYKLSANLTETRSHQTGPVEDNAKC----YPPPSVRACTQKL 99

  Fly   132 -PTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII--EHEVPDAVVANDANSSTVAFIA 193
             .|||.||:||:|.|.:||.||||::||.|....|:::..:  .|...:..::....|..:|.:.
Zfish   100 ESTDNVNKLLLVDYAGNRLAACGSIWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAKESDGMAGVV 164

  Fly   194 PGPPQHPVT------NVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAV 242
            .|.....:.      :.:::|......|.|   .|.::||.|    |...||      :..||.:
Zfish   165 VGDDDGDLKKKKKGGSRLFIGAAIDGKSEY---FPTLSSRKLVADEESVNMFSLVYQDEFVSSQI 226

  Fly   243 TTGTRTFINSYARETYFVNYVYGFSSERFSYFLT----TQLKHSHHSSPKEYITKLVRICQEDSN 303
            ...:.|.....|.:.|   |||||||..:.||||    |||.....:..|.:.:|:||:|..|:.
Zfish   227 KIPSDTLSQYPAFDIY---YVYGFSSRTYIYFLTLQLDTQLTQVDVTGEKFFTSKIVRMCSNDTE 288

  Fly   304 YYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTN 366
            :|||.|.|:.|..|   |.::.||||.:..:|...|||:||:|..:||||.:||:|:.|  .|..
Zfish   289 FYSYVEFPLGCTKD---GVEYRLVQAAYKHRPGKILAQALGLSEDEDVLFVIFSQGQKNRANPPR 350

  Fly   367 NSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGG 430
            .:.||:::|..|.....:.||||:.|.|...|.: ::..:||:.|..| ||:|||||.:|.||||
Zfish   351 ETVLCLFTLHQINLAMRERIKSCYRGEGKLSLPWLLNKELPCINTPKQ-IGDDFCGLVLNQPLGG 414

  Fly   431 ETPITSVPVAMFNTK---LTSVAATSTSGYTVVFVGTSDGFLKKVVIES----SSIANEYASFAV 488
            ...|..:|  :|:.:   :.||||.:...::||||||..|.|||:.:..    |..|..|.:..|
Zfish   415 LMVIEGIP--LFDDRTDGMASVAAYTYGDHSVVFVGTRSGHLKKIRVNGVPPPSENALLYETVTV 477

  Fly   489 DLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRS 553
            ..||.|.|||.|.....|||::|..:||::.|..||.|.:|..|||:.||:||||.|.||||.:.
Zfish   478 VEGSPILRDMVFSPDYQYIYLLSDKQVSRLPVESCSQYSSCKTCLGSGDPHCGWCVLHNKCSRKE 542

  Fly   554 NCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTART-LELIIDHLPQLKENLICAFTTEDKAL 617
            .|:..| :||:: |.:..:|..|| |.|..:..|:..| |.:.:.::|.|...:.|.|  |:...
Zfish   543 ACEKWA-EPLHF-STELKQCVDIT-VTPDNMSVTSVSTQLSVKVANVPNLSAGVTCVF--EELTE 602

  Fly   618 FTNATKKRNGVNCTTPRTDMLPQIEQG---KHHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHSSC 678
            ..........:.|.:|....:|.:.||   |.  ..|||:::: .|...::|||.|::||...||
Zfish   603 SPGEVLAEGQILCMSPSLRDVPSVTQGYGDKR--VVKLSLKSKETGLKFITTDFVFYNCSVLQSC 665

  Fly   679 TRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG-----PGFCPTINATGDGS 738
            :.||||.|||:||...|.||::.|| |              |::.|     .| ||.|..:   |
Zfish   666 SSCVSSSFPCNWCKYRHICTNNVAE-C--------------SFQEGRVSSAEG-CPQILPS---S 711

  Fly   739 EVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSMEFQYT-SR 800
            ::||..|..:.|.::...:.| ...|..:.|.|||:|:|..:.| :.....|.|.:..:.|. :.
Zfish   712 DILVPAGIVRPITLRARNLPQPQSGQKNYECVFNIQGKVQRIPAVRFNSSCIQCQNTSYWYEGNE 776

  Fly   801 SPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQC 865
            ..:|...|:::|.|..|:|.|.::..::|:|....||||:||.....:.||||.:...|.:::.|
Zfish   777 MGDLPVDFSIVWDGDFPIDKPSSMRALLYKCEAQRDSCGLCLKADSTFECGWCLADKKCLLKQHC 841

  Fly   866 NKNKEGKTDWLN---RSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGIN 927
               ...:.:|::   |:..|.:|.|...:|.|||.||||.:||.|.|||....:| :.||:||:.
Zfish   842 ---PSAEHNWMHQGRRNIRCSHPRITKIRPLTGPKEGGTRVTIEGENLGLQVREI-THVRVAGVR 902

  Fly   928 CMPFPQFYIDTKQIVCTVDS------PGEQMYRNGKIVVQIGD----YRGESKEDYEFVDPKILD 982
            |.|....||..::|||.::.      ||      |.:.:.|||    ||.:|.:.|.||.|....
Zfish   903 CNPAAAEYISAERIVCDMEESLMSSPPG------GPVELCIGDCSAEYRTQSTQTYSFVMPSFSR 961

  Fly   983 FNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRT--SASPGIIEGRLK 1045
            ..|:.||.||||.:.|:|:||:|||.:...:... .|..:.....:.:|.|  ||| |.....:|
Zfish   962 VRPEKGPVSGGTRLTISGRHLDAGSAVTVFLAQE-ECLFVRRTVREIVCVTPPSAS-GSGPSSVK 1024

  Fly  1046 MSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVV 1110
            :..|.. ...:|..:.|..||.:..:....|        |..|...::||||...:||.|.:...
Zfish  1025 LFIDKA-EITSDTRYIYTEDPNISTIEPNWS--------IINGSTSLTVTGTNLLTIQEPKVRAK 1080

  Fly  1111 YNGEMYASPCRVQSDTEMECASPVV-----DVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHN 1170
            |.|....:.|.:.:|:.|.|.:|.:     :.....:..:     |:||::|:   |..|..::.
Zfish  1081 YGGVETTNICSLVNDSVMTCLAPGIIYTKREAPESGVHPD-----EFGFILDH---VSALLILNG 1137

  Fly  1171 NHFELYPNPEY------FIFEERVKYFKSEYLTINGRNLDRACKES---DVEVKIGNGFCNITSL 1226
            ..|..||||.:      .|.|.:    ....:.:.|:||......:   :..|.||...|.:| :
Zfish  1138 TPFTYYPNPTFEPLGNAGILEVK----PGSPIILKGKNLIPPAPGNIRLNYSVTIGETPCLLT-V 1197

  Fly  1227 SRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILS-YESSNIILDWGENVIFAVIATIVI 1290
            |..||.|..|       .:.|.:.::.:...|||..|:|. |..|.:.|.    .|..:.|...:
Zfish  1198 SESQLLCDSP-------DLTGEQRVMILVGGLEYSPGMLHIYSDSTLTLP----AIIGIGAGGGV 1251

  Fly  1291 LLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIP 1355
            ||:..:|:|:|||:|:.::.|.|:.:|.|||.||.|||.|||||||||||::.:||.|:....||
Zfish  1252 LLIAIIAVLIAYKRKTRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIQELTNDMDGVKIP 1316

  Fly  1356 FLDYRSYAMKILFPNHEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMR 1420
            ||:||:|.|:::||..|:|.||: |.......||.||:|.||:.||.|||.||.|||:.|.||||
Zfish  1317 FLEYRTYTMRVMFPGIEEHPVLK-ELDSPANVEKALRLFSQLLHNKMFLLTFIHTLEAQRSFSMR 1380

  Fly  1421 ERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLL 1485
            :|.|||||:|..||.::||.|.:||.||.|||||.:|.::|||||||||||||||||:.||||||
Zfish  1381 DRGNVASLLMAALQGRMEYATVVLKQLLADLIEKNLENRNHPKLLLRRTESVAEKMLTNWFTFLL 1445

  Fly  1486 YKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPI 1550
            ::||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.||::         |..:
Zfish  1446 HRFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYK---------QLTL 1501

  Fly  1551 FCNNLDMLPSHTE---NVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGR 1612
            .|     :|...|   .:.||||:||||.|||:|.|:.:|:.||.||||:.||:|||||.|...|
Zfish  1502 MC-----IPPEGEAGTEIPVKVLNCDTITQVKDKLLDAVYKGIPYSQRPQADDMDLEWRQGRLTR 1561

  Fly  1613 VILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISK 1677
            :||.|||||:|.||:||:||||.||.|.||:.::||.||.|.||.:..........:||:|   .
Zfish  1562 IILQDEDVTTKIESDWKRLNTLAHYQVTDGSLVALVQKQVSAYNIANSFTFTRSLSRYESL---L 1623

  Fly  1678 YTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQK 1742
            .|||||...|:.:|:.....|.|.:.|||||:|:...|:||:|.:|:||||||||||||||||||
Zfish  1624 RTSSSPDSLRSRAPMITPDQETGTKLWHLVKNHEHADQREGDRGSKMVSEIYLTRLLATKGTLQK 1688

  Fly  1743 FVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNP 1807
            ||||||||:||||||||||||||||||||||:||....||||:|.||||||.||||||||:||||
Zfish  1689 FVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADKRQITDPDVRHTWKSNCLPLRFWVNVIKNP 1753

  Fly  1808 NFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRD 1872
            .|||||||::|.|:||||||||||||||||:|||||||||:|||||||||.|:.||:||||||..
Zfish  1754 QFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDISK 1818

  Fly  1873 MSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQ 1937
            |..||||||:|.|.|:||||..||||..||.|||.|..||.|::...|:.|.:.:|.:|..||||
Zfish  1819 MPSISDQDMDAYLVEQSRLHGNEFNTLSALSELYFYINKYKEEILTALDRDGYCRKHKLRHKLEQ 1883

  Fly  1938 VHNIMS 1943
            ..|:||
Zfish  1884 AINLMS 1889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	171/482 (35%)
		PSI	522..574	CDD:279745	23/51 (45%)
		PSI	671..>699	CDD:279745	15/27 (56%)
		PSI	830..883	CDD:279745	15/55 (27%)
		IPT_plexin_repeat1	885..977	CDD:238585	39/101 (39%)
		IPT_plexin_repeat2	978..1063	CDD:238584	25/86 (29%)
		IPT	1078..1177	CDD:301692	23/103 (22%)
		IPT_PCSR	1196..>1255	CDD:238337	14/61 (23%)
		Plexin_cytopl	1353..1916	CDD:285529	354/565 (63%)
plxna3	NP_001091959.1	Sema	30..510	CDD:301699	173/486 (36%)
		PSI	511..554	CDD:279745	22/44 (50%)
		PSI	807..852	CDD:214655	14/47 (30%)
		IPT_plexin_repeat1	861..955	CDD:238585	38/100 (38%)
		IPT	957..1042	CDD:301692	26/87 (30%)
		IPT_plexin_repeat3	1044..1144	CDD:238586	25/115 (22%)
		IPT_PCSR	1156..1225	CDD:238337	18/80 (23%)
		Plexin_cytopl	1315..1862	CDD:285529	354/564 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1364	1.000	Inparanoid score	I128
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm24994
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960