DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexA and plxnb2a.1

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_001155072.1 Gene:plxnb2a.1 / 561433 ZFINID:ZDB-GENE-030131-8917 Length:1864 Species:Danio rerio


Alignment Length:1987 Identity:634/1987 - (31%)
Similarity:1018/1987 - (51%) Gaps:285/1987 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 TKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAV---RSPTD 134
            |.:|:::.|..|||:::|.||.::||:.:|:......|||:.|:.:|:   .|:.|.   ....|
Zfish    31 TIINNVVQDPQTGRIYLGAVNGIFQLNHNLQEEGRADTGPKKDNPQCT---PPITAQCTDAKEMD 92

  Fly   135 NYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVS----IIEHEVPDAVVANDANSSTVAFIAPG 195
            |:||:||::.|...||.|||||:|.|::.||.:|:    ..:.:.....||:...|.||..:. .
Zfish    93 NFNKLLLVNSANGTLIVCGSLFRGICSLVNLNSVNKPVYYSDTKGEKTYVASTEESVTVVGVI-S 156

  Fly   196 PPQHPVTN----VMYVGVTYTNNSPYRSEIPAVASRSLE---KTKMFQIASSAVTTGTRTFINSY 253
            ..:...||    |..||..|.::...:    .:::|.|:   :..:|:....|.|..|..|:..|
Zfish   157 YFKDTTTNANLSVFLVGKGYGSSDSSK----LISTRLLQEHGEMDVFENMVEASTVQTSAFVLRY 217

  Fly   254 ARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVEC-ISD 317
            ..:     :.|.|....:.|||   ...|..:|....||.:.|:|:.|.:||||||:.:.| ::.
Zfish   218 HHD-----FRYTFKDNGYIYFL---FSRSPGTSDSTKITFIARLCENDHHYYSYTELQLNCTVNT 274

  Fly   318 AQGGTKFNLVQAGFLGKPSSDLAQSLGIS-IQDDVLFAVFSKGEGNTPTNNSALCIYSLKSIRRK 381
            .|.|..||.|||.:|.||..||||::..| :.|.|||.|||..|.:   ..||||:|.|.||..:
Zfish   275 EQQGNTFNKVQAAYLAKPGKDLAQNIVPSNLNDKVLFGVFSADEAD---GRSALCMYPLSSINAR 336

  Fly   382 FMQNIKSCFNGSGMRGLDFISPSMPCVL-----TKLQTIGED----------FCGLD-VNSPLGG 430
            |.:.|:||:.|      :.:....|..:     :|.:.|.:.          .||.: :.|||..
Zfish   337 FEEVIESCYTG------EVLEDDKPKTVYSPYNSKNEAICKTKRDKNMVKAYICGAEFLPSPLAS 395

  Fly   431 --ETPITSVPVAMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIES------SSIANEYASFA 487
              |..:...|:...|..||:||....:.:||.|:|||...:.||.::.      :.|..:.|..|
Zfish   396 KPEYALAVKPIYTRNDMLTAVAVAVENEHTVAFLGTSGADVLKVHLDPNHTDFYNRIPGDRADGA 460

  Fly   488 VDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPR 552
            |      |:::.||:...::|:.:..|:|||.|..|...:.|..|:..||||||||.||.:|:.:
Zfish   461 V------NKNLLFDSTLNHLYITTGKKISKVSVQACEQREDCHSCVSQRDPYCGWCVLEGRCTRK 519

  Fly   553 SNC-QDDANDPLYWVSYKTGKCTTITSVVPHQL--QRTTARTLELIIDHLPQLK--ENLICAFTT 612
            .:| :.|..:...|...:|  |.||.|..|..:  ::|.:..:.:.|..||.:.  :.|.|.|  
Zfish   520 KDCRKGDGENAWLWSPKQT--CVTIQSFEPPNISCKKTDSTQVVINIPSLPSISSPDRLECVF-- 580

  Fly   613 EDKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDC----- 672
              ....:.|..:...|.|..|.:|.:|...:.:......:.:...:..::.|:.|.|::|     
Zfish   581 --DGYRSQAKMEDTRVTCYLPSSDYIPPTPETQDFVAVPVKITVNDKIEVASSVFEFYNCAGVVK 643

  Fly   673 -STHSSCTRCVSSEFPCDWCVEAHRCT--HDTAENCRNDILVTGVSRIGPSY------RSGPGFC 728
             |.::.|..||:|::.|.|.::.|.|:  .|:|..  :.|:....:.:.|.:      |...|:.
Zfish   644 KSENTPCIACVTSKWGCQWNIQDHTCSDKDDSAHG--SHIIGNMEANLCPQFEIPEPLRIPVGYK 706

  Fly   729 PTINATGDGSEVLVAGGTSKSIKVKVHI---IGQFIVQTRFVCQFNIEGRVTSLNAQLLGDTIYC 790
            ..|...|...::.    ..|:.::...:   :|:..|:...: ::..||                
Zfish   707 TPITFHGKNLDIY----WGKTFQIGTELMKQVGEVTVEADGL-KYRFEG---------------- 750

  Fly   791 DSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNI----HVVIYRCREMADSCGICLALSEKYNCG 851
              .||.| .:.|.:..||.:     |..|....|    .||:|.|....:.|.:|....:..:|.
Zfish   751 --YEFAY-DKEPEVNVTFYI-----KDKDTDRKIDSTLRVVLYNCSVRREDCSLCKNAHKNDSCV 807

  Fly   852 WCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYND 916
            ||.:|.:|.....|:          |....||.|:|....|:.||..|..::||:|.|||....|
Zfish   808 WCDTTKSCIYRSLCD----------NELHQCPPPKITDIVPRYGPMNGRISVTIKGSNLGIKKED 862

  Fly   917 IYSGVRIAGINCMPFPQFYIDTKQIVCTV---DSPGEQM----YRNGKIVVQI-GDYRGESKEDY 973
            | ..:.:|.:.|:..|:.|..:..:||.:   .||.|.:    .::|.:.|.: |:..|.|:.::
Zfish   863 I-KKITVAKVPCIHQPERYSVSTSVVCEIGPFPSPPEDLPISPSKSGPVEVLVEGERTGTSEVEF 926

  Fly   974 EFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASIN-DHLPCKILSTDSSQAICRTSASP 1037
            .:.||......|..||.:|||.|.|||:.|::.|:...:|. |..||::| |...:..|||....
Zfish   927 TYRDPVPEAVFPVKGPAAGGTVITITGQDLDSASKDDITITVDKEPCEVL-TFGHEITCRTGPYK 990

  Fly  1038 G--IIEGRLKMSFDNGPREFNDYN-FKYVLDPTVEHVSSGPSGQIKVPKGIP-----AGGIRISV 1094
            |  |...:|.:....|.......: |:|..||             |:.:..|     .||.||.|
Zfish   991 GQKIPSDKLPVIVKYGKDTVKTVDAFEYSPDP-------------KISEYFPQTSFVCGGRRILV 1042

  Fly  1095 TGTQFTSIQNPNIYVVYNGEMY---AS------PCRVQSDTEMECASPVVDVDSHVIEAERPILL 1150
            .|:.|..:|...:.|:.:.:.:   ||      ....:::|.:|..||||: .:::..:.|.:: 
Zfish  1043 IGSGFDQVQRATMRVLPSSDEFDVKASNVEFFQEVEKKNETTLEFLSPVVN-KTYINLSLRTVI- 1105

  Fly  1151 EYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVK 1215
                .:||:  |.||:     .|..:|:|.:...:::. ..:...:.:|||...:|....:.:..
Zfish  1106 ----QLDNL--VLNLT-----DFAYHPDPHFNKLKDKA-ITEGSIINVNGRGFAKAMTAKEAQAF 1158

  Fly  1216 IGNGFCNITSLSRQQLTCRPPS---EATATK-----SMNGPEVIVRIGTSLEYRIGILSYESSNI 1272
            :|:..|.:|.|...:|....||   ::|:.:     |.:..|::::.|.. |:.:|.:.:|... 
Zfish  1159 VGDESCLVTILEDDKLFLVAPSSPPKSTSRRHRRDTSSDALELLIKFGNG-EWNVGSVRFERKY- 1221

  Fly  1273 ILDWGENVIFAVIATIVILLLIFVAL-LVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFA 1336
                 |..::.:|..::|.:::|:|: :..|::||.::.|....::.|:..||..|...|.:.|.
Zfish  1222 -----EVPLYIIIPAVLIPMVLFIAVSIYCYRRKSQQAEREYEKIKNQLANLEESVRDRCTKEFT 1281

  Fly  1337 ELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHED-----HIVLQWERPELLRK--EKGLRIF 1394
            :|..||.|.|.||:...||||||::|..::.|...:|     .|..:.:.|:..|.  ::.|..|
Zfish  1282 DLMIEMEDHTSDLSEARIPFLDYKNYTDRVFFLPSKDGANDVMITGKLDIPDNRRAIVDQALNQF 1346

  Fly  1395 GQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGK 1459
            ..|:.:||||:.||||||..:.|:.|.:|..|||:.|.|..||||.|||::|||.:|:|:.:..|
Zfish  1347 SNLLNSKTFLINFIRTLEGRQEFNARNKVYFASLLTVALHGKLEYYTDIMRTLLLELMEEYVHSK 1411

  Fly  1460 SHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSL 1524
             :|||:|||:|:|.|:||..|.:..||:|||:.||||||.||:|:|.||:||||||...:|:|:|
Zfish  1412 -NPKLMLRRSETVVERMLCNWMSICLYQFLKDSAGEPLYKLFKAIKHQVEKGPVDAKMKKAKYTL 1475

  Fly  1525 SEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRN 1589
            ::..|:...:::..:.     :|..:.....|:.|       ||||:||||.|||||.:|.:|||
Zfish  1476 NDTGLLGDDVEYSILT-----LQVLVHGEGPDVTP-------VKVLNCDTISQVKEKIIEQVYRN 1528

  Fly  1590 IPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSI 1654
            :|.||||..|.:.||||.|:||: ||.|.|:||:.|..||::|||.||||.|||           
Zfish  1529 LPYSQRPVVDSVALEWRPGSTGQ-ILSDLDLTSQKEGRWKRINTLAHYNVRDGA----------- 1581

  Fly  1655 YNFSILSDKNEKSHKYETLNISKYTSSSPTFSRAGSPLNNDMHE--NGL----RYWHLVKHHDSD 1713
                             ||.:|:...:..:|.:     |.|.||  |.|    :.:|||:..|..
Zfish  1582 -----------------TLVLSRVLHTQQSFDQ-----NMDNHEERNALLEDDKVFHLVRPADEL 1624

  Fly  1714 MQKEGER-------VNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDF 1771
            .:.:.:|       ..|.::||||||||:.|||||:||||.|.::..:   |:.:|.|:||.|||
Zfish  1625 EEVKSKRGSMKDKATTKAITEIYLTRLLSMKGTLQQFVDDFFRSVLCS---GTVVPPAVKYFFDF 1686

  Fly  1772 LDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCST 1836
            ||:|||.|...|.|.:|.||:||||||||||::|||:|:||:|.:.:||:.|||:||||||:|:.
Zfish  1687 LDEQAQKHDNVDDETIHIWKTNSLPLRFWVNILKNPHFIFDVHLTEVVDASLSVIAQTFMDACTK 1751

  Fly  1837 SDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCA 1901
            ::|:|.::|||:||||||:|..|:|.||.||:.||.|.|:||||||..|||.||.||.:.||..|
Zfish  1752 TEHKLTRESPSNKLLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRSHTDKLNTQAA 1816

  Fly  1902 LHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQV 1938
            ||:||.||.||.:.:..:||||..:|.::|..:|:|:
Zfish  1817 LHQLYQYASKYYDGIISSLEEDPAAQSKQLTLRLQQI 1853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 146/484 (30%)
PSI 522..574 CDD:279745 18/52 (35%)
PSI 671..>699 CDD:279745 10/35 (29%)
PSI 830..883 CDD:279745 10/52 (19%)
IPT_plexin_repeat1 885..977 CDD:238585 28/99 (28%)
IPT_plexin_repeat2 978..1063 CDD:238584 27/88 (31%)
IPT 1078..1177 CDD:301692 26/112 (23%)
IPT_PCSR 1196..>1255 CDD:238337 14/66 (21%)
Plexin_cytopl 1353..1916 CDD:285529 265/582 (46%)
plxnb2a.1NP_001155072.1 Sema_plexin_B2 26..488 CDD:200537 147/487 (30%)
PSI 490..534 CDD:279745 16/43 (37%)
PSI 786..829 CDD:214655 10/52 (19%)
IPT 831..930 CDD:301692 28/99 (28%)
IPT_PCSR 931..1020 CDD:238337 28/89 (31%)
TIG 1022..1119 CDD:280079 27/122 (22%)
Plexin_cytopl 1299..1831 CDD:285529 265/581 (46%)
UBQ 1492..1585 CDD:214563 54/128 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.820

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