DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxna2

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_689780.5	Gene:	plxna2 / 561285	ZFINID:	ZDB-GENE-090311-6	Length:	1902	Species:	Danio rerio

Alignment Length:	1959	Identity:	807/1959 - (41%)
Similarity:	1156/1959 - (59%)	Gaps:	200/1959 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 NHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SILDCPLNAVRSPTDNYNK 138
            |||.|...||.:::|.|||:|:||.:|.|..:..|||::|:..|  .::..|.:.....|:|.||
Zfish    54 NHLTVHKTTGALYIGAVNRVYKLSGNLTLLVSHDTGPEDDNKACYPPLIVQPCSEPLISTNNINK 118

  Fly   139 VLLIDRATSRLIACGSLFQGTCTVRNLQNVSII---EHEVPDAVVANDANSSTVAFIAPGPPQHP 200
            :||||.:.:||:|||||:||.|.:..|.::.|:   .|:....:.:.:...:....|.|...:
Zfish   119 LLLIDYSQNRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNQTGTMYGVIVPSQGK-- 181

  Fly   201 VTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKM--FQIASSAVTTGTRTFINSYARETYF 259
             ...:::|........|   .|.::||.|    |.:.|  :::.:..|::..:...::.|..::|
Zfish   182 -DGTLFIGTAVDGKQDY---FPTISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTLALVSHF 242

  Fly   260 -VNYVYGFSSERFSYFLTTQ-------LKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECIS 316
             :.|:|||:|..|.||||.|       :..|..|:...|.:::||:|::|..::||..:|:.|:
Zfish   243 DIYYIYGFASGNFVYFLTVQPETPENSMSSSGPSNDLFYTSRIVRLCKDDHKFHSYVSLPIGCV- 306

  Fly   317 DAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEG--NTPTNNSALCIYSLKSIR 379
              :...::.|:||.:||||....|.||.||.||||||||||||:.  :.|.::||||::|::.|.
Zfish   307 --RNRVEYRLLQAAYLGKPGRVFAASLNISAQDDVLFAVFSKGQKQYHHPPDDSALCVFSIRDIN 369

  Fly   380 RKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQT-IGEDFCGLDVNSPLGGETPITSVPV-AM 441
            .:..:.::||:.|.|...|:: :...:||  ||... |.:.|||||:|.||||...:|...: ..
Zfish   370 ARIKERMQSCYQGEGNLELNWLLGKDVPC--TKAPVPIDDSFCGLDINQPLGGSQLVTGHTLYTE 432

  Fly   442 FNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIE---SSSIANEYASFAVDLGSEINRDMQFDNQ 503
            ...::|||.:...:|:.|.||||..|.|||:.::   ...:..|..|...| |:.|.|||.|...
Zfish   433 SRDRMTSVTSYVYNGFCVAFVGTKSGRLKKIRVDGPPQGGVQYETLSVIKD-GNSILRDMAFSLD 496

  Fly   504 NLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSY 568
            |.||||||:.:|::|.:..|..|.|||:||.:.||:||||.|.|.||.|..| :.||:| |..:.
Zfish   497 NSYIYVMSERQVTRVPIESCEQYSTCGECLSSGDPHCGWCVLHNICSQRDRC-ERANEP-YRFAA 559

  Fly   569 KTGKCTTITSVVPHQLQRTTARTLELI-IDHLPQLKENLICAFTTEDKALFTNATKKRNGVN--- 629
            ...:|...| |.|..:..:......|: :..:|.|...:.|:        |.|.|:....||
Zfish   560 TLNQCVKAT-VYPDSIAVSEPSVPLLVKVTDVPDLSAGITCS--------FGNLTEVEGRVNGNQ 615

  Fly   630 --CTTPRTDMLPQIEQGKHHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWC 691
              |.:|....:|.|...:.....:|.:.:: .|..|:||:..|::||.|..|..||:|.|.|.||
Zfish   616 ILCISPAAKDVPIIPADQDWSGVELRLNSKETGQMLISTEVKFYNCSVHQLCLSCVTSSFRCHWC 680

  Fly   692 VEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGD------GSEVLVAGGTSKSI 750
            ...:.||||.: :|              |::.|     .:||:.|      ..|:|:..|..|.|
Zfish   681 KYRNLCTHDPS-SC--------------SFQEG-----RVNASEDCPQLVRSEEILIPAGEVKPI 725

  Fly   751 KVKVHIIGQ-FIVQTRFVCQFNIEG---RVTSLNAQLLGDTIYCDSMEFQYTS-RSPNLTATFAV 810
            .:|...:.| ...|..:.|..:|:|   |||:|  :....::.|.:..:.|.. |...|...|:|
Zfish   726 TLKARNLPQPQSGQRGYECVLHIQGVSHRVTAL--RFNSSSVQCQNSSYLYEGMRISELPVDFSV 788

  Fly   811 IWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDW 875
            :|.|:..:|||.||.|.:|:|....||||:||....|:.|||||....|.:.:.|.......:.|
Zfish   789 VWNGNFIIDNPENIKVHLYKCGAQRDSCGVCLKAERKFQCGWCSMEGRCTLRQHCPMTNPYTSRW 853

  Fly   876 LNRSEI---CPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYID 937
            |:.:..   |.||.|....|..||.||||.:||||:|||.:::|:.:.|::||:.|.|....||.
Zfish   854 LHLASTNVKCTNPRITEVTPVAGPPEGGTRVTIRGVNLGLSFSDMVNNVQVAGVQCTPQENGYII 918

  Fly   938 TKQIVCTVD-SPGEQMYRNGKIVVQIGDYRGE----SKEDYEFVDPKILDFNPKFGPTSGGTEIH 997
            .:||||.:| :|.:.  :.|.:.:.:|:.:.|    |.:.|.||.|.:...:|..||.||||::.
Zfish   919 AEQIVCEMDAAPVDS--KAGPVHLCVGECKPELQTRSSQLYSFVMPSVTGLSPSRGPESGGTKVT 981

  Fly   998 ITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSAS-PGIIEGRLKMSFDNGPREFND-YNF 1060
            |.|::|.|||.:.....:. .|:......::.:|.::.| .|:...::.:|.|..  :..| ..|
Zfish   982 IMGENLGAGSSVTVLFGNQ-TCEFYERTMTEIVCYSAPSLTGVGSVQISVSVDRA--QVRDILAF 1043

  Fly  1061 KYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQS 1124
            :|:.||||:.:.         |: .|.:|...:.||||....||.|.|.:.|.|....:.|:|.:
Zfish  1044 EYIDDPTVQRIE---------PEWSIASGHTPLVVTGTNLDVIQEPRIRIKYGGRESVNVCKVLN 1099

  Fly  1125 DTEMECASPVVDVD-----SHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYF-- 1182
            .|.|.|.:|.:..:     ..|..|:     |:||:.:|   ||.|...:|.:|..|||| :|
Zfish  1100 TTTMSCFAPSLTAEYRPGLDSVKHAD-----EFGFIFNN---VQALLVYNNTNFMYYPNP-FFEP 1155

  Fly  1183 -----IFEERVKYFKSEYLTINGRNLDRACK---ESDVEVKIGNGFCNITSLSRQQLTCRPPSEA 1239
                 :.|::    ....:.:.|:||..:..   :.:..|.||...|::| :|..||.|.||
Zfish  1156 LSTNGVLEQK----PGSPIILKGKNLVPSAAGGVKLNYTVLIGETPCSVT-VSESQLLCEPP--- 1212

  Fly  1240 TATKSMNGP-EVIVRIGTSLEYRIGI-LSYESSNIILDWGENVIFAVIATIV----ILLLIFVAL 1298
                ::.|. :::|::|       |: :|..|.||:.|  ..:....|.:|.    :||:|.:.:
Zfish  1213 ----NLTGQYKIMVQVG-------GLHVSPGSVNILSD--SLLTLPAIVSIAAGGGLLLIIVILV 1264

  Fly  1299 LVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYA 1363
            |:|||:||.|:...|:.:|.|||.||.|||.|||||||||||::.:||.||...|||:||||:||
Zfish  1265 LIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRAGIPYLDYRTYA 1329

  Fly  1364 MKILFPNHEDHIVLQWERPEL-------LRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRE 1421
            |::|||..|||.||:    ||       |..||.|::|.|||.||.|||.||||||..|.||||:
Zfish  1330 MRVLFPGIEDHPVLR----ELEVSGNGQLCVEKALKLFAQLINNKVFLLTFIRTLEMQRSFSMRD 1390

  Fly  1422 RVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLY 1486
            |.|||||||..||.:|||.||:||.||.|||:|.:|.|:|||||||||||||||||:.||.|||:
Zfish  1391 RGNVASLIMTALQGRLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFAFLLH 1455

  Fly  1487 KFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIF 1551
            |||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.||::           .:.
Zfish  1456 KFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYK-----------TLI 1509

  Fly  1552 CNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILY 1616
            .|.::....::..:.||||:||||.|||||.|:.:|:|:|.||||:..|:|||||.|...||:|.
Zfish  1510 LNCVNPENENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSQRPKAVDMDLEWRQGRMARVVLQ 1574

  Fly  1617 DEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSS 1681
            |||:|:|.|::||:||||.||.|.|...::|||||:|.||....:..:..|       ||:|.|:
Zfish  1575 DEDITTKIENDWKRLNTLMHYQVSDRCVVALVPKQTSSYNIPPTTSISRTS-------ISRYDST 1632

  Fly  1682 -----SPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQ 1741
                 ||...|:.:|:.....|:|::.|||||:|:...||||:|.:|:|||||||||||||||||
Zfish  1633 FRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQ 1697

  Fly  1742 KFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKN 1806
            |||||||||:|||.||||||||||||||||||:||..|||.|.:|.||||||.||||||||:|||
Zfish  1698 KFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADKHGIHDTDVRHTWKSNCLPLRFWVNVIKN 1762

  Fly  1807 PNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIR 1871
            |.||||||||:|.|:||||||||||||||||:|||||||||:|||||||||.|:.||:|||.||.
Zfish  1763 PQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKNWVERYYADIS 1827

  Fly  1872 DMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLE 1936
            .:..||||||||.|||::|||::|||...||:|:|:|..||:|::|..|::||.::|||||:|:|
Zfish  1828 RLPAISDQDMNAYLAEQARLHSSEFNMLSALNEIYSYISKYSEEITAALDQDETAKKQRLAYKVE 1892

  Fly  1937 QVHNIMSSE 1945
            |:...||.|
Zfish  1893 QLIAAMSLE 1901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	160/470 (34%)
		PSI	522..574	CDD:279745	23/51 (45%)
		PSI	671..>699	CDD:279745	12/27 (44%)
		PSI	830..883	CDD:279745	17/55 (31%)
		IPT_plexin_repeat1	885..977	CDD:238585	36/96 (38%)
		IPT_plexin_repeat2	978..1063	CDD:238584	22/86 (26%)
		IPT	1078..1177	CDD:301692	30/104 (29%)
		IPT_PCSR	1196..>1255	CDD:238337	16/62 (26%)
		Plexin_cytopl	1353..1916	CDD:285529	356/574 (62%)
plxna2	XP_689780.5	Sema	41..557	CDD:301699	183/516 (35%)
		PSI	660..707	CDD:279745	21/66 (32%)
		PSI	811..>844	CDD:279745	13/32 (41%)
		IPT_plexin_repeat1	866..960	CDD:238585	35/95 (37%)
		IPT_plexin_repeat2	962..1045	CDD:238584	22/85 (26%)
		IPT_plexin_repeat3	1049..1149	CDD:238586	33/116 (28%)
		TIG	1167..1235	CDD:280079	20/82 (24%)
		Plexin_cytopl	1319..1872	CDD:285529	356/574 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56427
Inparanoid	1	1.050	1364	1.000	Inparanoid score	I128
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm24994
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970