DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxna1b

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001103480.1	Gene:	plxna1b / 558065	ZFINID:	ZDB-GENE-061007-1	Length:	1885	Species:	Danio rerio

Alignment Length:	2015	Identity:	822/2015 - (40%)
Similarity:	1139/2015 - (56%)	Gaps:	225/2015 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WLPSRTGCQTLAANIWSDKT-------TAQNEPINLTNANAPIKNAKNLNSTITNVAAFDTKLNH 77
            |.|....|      |.|.||       |..|.|.:...|..|.:          :....|..|.|
Zfish     2 WPPQGPQC------IISPKTVVLLGLLTICNSPHHSEGALEPFR----------SFTPPDWGLTH 50

  Fly    78 LLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAVRSPTDNYNK 138
            |.:...||.|:||.||.:|:||.:|....:..|||..|:.:|    |:..||.:.  ||..|.||
Zfish    51 LAIHNKTGDVYVGAVNWIYKLSSNLTKLRSHVTGPVVDNEKCYPPPSVQSCPHDL--SPNSNVNK 113

  Fly   139 VLLIDRATSRLIACGSLFQGTCTVRNLQNV---------------SIIEHEVPDAVVANDANSST 188
            :||||...:|||||||..||.|....|.::               |::|......|:.::.:.|.
Zfish   114 LLLIDYPQNRLIACGSTSQGICQFLRLDDLFKLGEPHHRKEHYLSSVVESGTMSGVIISEGHLSK 178

  Fly   189 VAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVT 243
                            :::|......|.|   .|.::||.|    |...||      :..||.:.
Zfish   179 ----------------LFIGTPIDGKSEY---FPTLSSRKLMANEEDADMFSFVHQDEFVSSQLK 224

  Fly   244 TGTRTFINSYARETYFVNYVYGFSSERFSYFLT----TQLKHSHHSSPKEYITKLVRICQEDSNY 304
            ..:.|.....|.:.|   |:|.||||:|.|:||    |||.....|..:.:.:|:||:|.:|..:
Zfish   225 IPSDTLSKFPAFDIY---YIYSFSSEQFVYYLTLQLDTQLTSPDASGEQFFTSKIVRLCIDDPRF 286

  Fly   305 YSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTNN 367
            |||.|.|:.|..|   |.::.|:|..:|.||...||.|||:|.|:|:||.|||:|:.|  .|...
Zfish   287 YSYVEFPIGCTKD---GVEYRLIQDAYLSKPGRQLANSLGVSEQEDILFTVFSQGQKNRVKPPRE 348

  Fly   368 SALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGGE 431
            ||||:::|..|:.|..:.|:||:.|.|...|.: ::..:||:.:.|| |.::|||.|.|.||||.
Zfish   349 SALCLFTLTKIKEKIKERIQSCYRGEGRLSLPWLLNKELPCINSPLQ-IDDNFCGQDFNQPLGGT 412

  Fly   432 TPITSVPVAMFNTK---LTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANE---YASFAVDL 490
            ..|...|  :|..|   :|||||....|.||||.||.:|.:||::|.|.|.:..   |.|.||..
Zfish   413 KTIEGTP--LFIDKDDGMTSVAAYDYRGNTVVFAGTRNGRMKKILINSVSPSRPALLYESVAVSE 475

  Fly   491 GSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNC 555
            ||.:.|||.|.....:||.::..:|::|.|..||.|.||.:||.:|||:||||.|.|.||.|..|
Zfish   476 GSPLLRDMLFSPDLQFIYTLTDKQVTRVPVERCSQYSTCSECLSSRDPHCGWCVLHNICSRRDRC 540

  Fly   556 QDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIID--HLPQLKENLICAFTTEDKALF 618
             :.|::|..:.| :..:|..:| |.|:.:..|.|. ::|::.  ::|.|...:.|:|  ||...
Zfish   541 -ERADEPQRFAS-RVDQCVELT-VQPNNISVTMAE-VQLVLQARNVPDLSAGVDCSF--EDYTQ- 598

  Fly   619 TNATKKRNGVNCTTPRT-DMLP--QIEQGKHHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHSSCT 679
            |..|...:.:.|.:|.. :::|  ::::..|  ..||.:::| .|....|.||||::||.|.||.
Zfish   599 TEGTIHGSRIYCLSPTAKELVPITRLQRDTH--VLKLYLKSRETGQKFASVDFTFYNCSIHRSCL 661

  Fly   680 RCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGD------GS 738
            .||:..|||.||...|.||.: |.:|              |::.|     .:|.:.|      .:
Zfish   662 SCVNGSFPCHWCKYRHLCTQN-ANDC--------------SFQEG-----RVNMSEDCPQILPST 706

  Fly   739 EVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSMEFQYT-SR 800
            |:.:..|..|.|.:....:.| ...|..:.|.|:|:|...|:.| :....:|.|....:.|. |.
Zfish   707 EIYIPVGVPKPITLSARNLPQPQSGQRNYECVFHIQGETHSVTALRFNSSSIQCQKTTYNYEGSD 771

  Fly   801 SPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQC 865
            ..:|....:|:|.|:..:|||:||...:|:|..:.:|||:||.....:.||||.....|.:.::|
Zfish   772 ISDLPVDLSVVWNGNFIIDNPYNIQAHLYKCYALRESCGLCLKADPSFECGWCVQDRKCSLRQEC 836

  Fly   866 NKNKEGKTDWLNR---SEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGIN 927
               .:.:..|::.   :..|.:|.|....|:|||.:|||.:||.|.|||..:.||.:||||..::
Zfish   837 ---AQPENTWMHATAGNSRCTHPRITKLSPETGPRQGGTRLTISGENLGLQFKDIQNGVRIGKVS 898

  Fly   928 CMPFPQFYIDTKQIVCTV-DSPGEQMYRNGKIVVQI------GDYRGESKEDYEFVDPKILDFNP 985
            |.|..:.||..:||||.: |:.|   ||..:..|::      .|||..|.:.:.||.|......|
Zfish   899 CQPIEEEYISAEQIVCRLADATG---YRVQEAHVEVCVRDCLQDYRAVSPKVFTFVSPYFTRVVP 960

  Fly   986 KFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDN 1050
            .:||.||||.|.|.|.||||||.:...|..: .|:.....:.:.:|.|.|  |:..|...:..|.
Zfish   961 SYGPISGGTRITIYGSHLNAGSAVSIKIGLN-TCQFERRSAREIVCVTPA--GLGSGGTPVMVDI 1022

  Fly  1051 GPREFN--DYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNG 1113
            ...|..  :..|.|..|||:.        :|:....|.:||..::|||....:::.|.:...|..
Zfish  1023 NAAELRNPEVKFNYTDDPTIL--------KIEPDWSIASGGTPLTVTGVNLATVREPKMRAKYGT 1079

  Fly  1114 EMYASPCRVQSDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPN 1178
            ....:.|.|.::|.|.||.|.|...............|.||:||:|    .:..|.|..|..||:
Zfish  1080 ISSVNNCTVLNNTVMVCAVPSVAGSERGFSEVGNAPDEIGFIMDHV----QMLLVVNESFSFYPD 1140

  Fly  1179 PEYFIFEERVKYFK-SEYLTINGRNLDRACKES---DVEVKIGNGFCNITSLSRQQLTCRPPSEA 1239
            |.:..|...:...| ...|.:.|:||..:...:   :..|.||:..|.:| :|..||.|..|
Zfish  1141 PVFEAFGPAMLELKPGSPLILKGKNLIPSAAGNYRLNYTVLIGDKQCVLT-VSETQLLCESP--- 1201

  Fly  1240 TATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIV-------ILLLIFVA 1297
                ::.|...:..:.....:..|.|...|.:::          .:..|:       :|||:.:.
Zfish  1202 ----NLTGQHKVTVLAGGFRFSPGTLQIYSDSLL----------TLPAIIGIGGGGGLLLLVIII 1252

  Fly  1298 LLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSY 1362
            :|:|||:||.::.|.|:.:|.||..||.|||.|||||||||||::.:||.||...||||||||:|
Zfish  1253 ILIAYKRKSRDADRTLKRLQMQMHNLESRVALECKEAFAELQTDIHELTQDLDGSGIPFLDYRTY 1317

  Fly  1363 AMKILFPNHEDHIVL-QWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVA 1426
            ||::|||..|||.|| :.|.|  ...||.|.:||||:..|.|||.||||||:.|.||||:|.|||
Zfish  1318 AMRVLFPGIEDHPVLKEMEVP--ANVEKALTLFGQLLNKKHFLLTFIRTLEAQRSFSMRDRGNVA 1380

  Fly  1427 SLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKE 1491
            ||||..||.::||.|.:||.||.|||:|.:|.|:|||||||||||||||||:.||||||||||||
Zfish  1381 SLIMSGLQGEMEYATGVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKE 1445

  Fly  1492 CAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLD 1556
            ||||||:||:.|:|.|::|||:|:.|.||||||||:|||||.||::.:.::         |.|
Zfish  1446 CAGEPLFMLYCAIKQQMEKGPIDSITGEARYSLSEDKLIRQQIDYKTLTLH---------CIN-- 1499

  Fly  1557 MLPSHTEN---VSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDE 1618
               ...||   |.||.|:|||:.|||||.|:.:::..|.||||:..|:|||||.|...|:||.||
Zfish  1500 ---PENENAAEVMVKCLNCDTVTQVKEKLLDAVFKGTPYSQRPKVGDMDLEWRQGRMARIILQDE 1561

  Fly  1619 DVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSP 1683
            |||:|.:::||:||||.||.|.||:.::|||||:|.||.|..|...:...:||    |...:|||
Zfish  1562 DVTTKIDNDWKRLNTLAHYQVTDGSLIALVPKQNSAYNISNSSTFTKSLSRYE----SMLRTSSP 1622

  Fly  1684 TFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLF 1748
            ...|:.:|:.....|:|.:.|||||:||...|:|.:|.:|:||||||||||||||||||||||||
Zfish  1623 DSLRSRTPMITPDLESGTKLWHLVKNHDHTDQREVDRGSKMVSEIYLTRLLATKGTLQKFVDDLF 1687

  Fly  1749 ETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDI 1813
            |||||||||||||||||||||||||:||..|.|:||:|.||||||.||||||||:||||.|||||
Zfish  1688 ETIFSTAHRGSALPLAIKYMFDFLDEQADRHMISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDI 1752

  Fly  1814 HKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISD 1878
            ||::|.|:||||||||||||||||:|:|||||||:|||||||||.|:.||:|||.||..||.|||
Zfish  1753 HKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKNWVERYYSDISRMSAISD 1817

  Fly  1879 QDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIMS 1943
            |||:|.|||:||||..:||:..||||:::|..||.:::...||.||.|::|||..|||||.:.|:
Zfish  1818 QDMSAYLAEQSRLHLNQFNSMSALHEIFSYITKYKDEILSALERDEQSRRQRLRAKLEQVIDTMA 1882

Fly 1944 1943
Zfish 1883 1882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	172/486 (35%)
		PSI	522..574	CDD:279745	23/51 (45%)
		PSI	671..>699	CDD:279745	14/27 (52%)
		PSI	830..883	CDD:279745	13/55 (24%)
		IPT_plexin_repeat1	885..977	CDD:238585	39/98 (40%)
		IPT_plexin_repeat2	978..1063	CDD:238584	27/86 (31%)
		IPT	1078..1177	CDD:301692	26/98 (27%)
		IPT_PCSR	1196..>1255	CDD:238337	15/61 (25%)
		Plexin_cytopl	1353..1916	CDD:285529	355/566 (63%)
plxna1b	NP_001103480.1	Sema_plexin_A1	35..506	CDD:200532	174/510 (34%)
		PSI	507..>549	CDD:279745	22/42 (52%)
		PSI	653..700	CDD:279745	21/66 (32%)
		PSI	802..847	CDD:214655	13/47 (28%)
		IPT_plexin_repeat1	856..951	CDD:238585	38/97 (39%)
		IPT_plexin_repeat2	953..1037	CDD:238584	27/86 (31%)
		IPT_plexin_repeat3	1040..1139	CDD:238586	28/110 (25%)
		TIG	1141..1224	CDD:280079	19/90 (21%)
		Plexin_cytopl	1308..1855	CDD:285529	355/566 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1364	1.000	Inparanoid score	I128
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm24994
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970